Results 71 to 80 of about 13,876,063 (349)

Improved construction of concrete viaducts with movable scaffolding systems in Spain [PDF]

, 2016
The current paper relates the state of the art of construction of viaducts with a movable scaffolding system (MSS). Two different procedures are introduced: the traditional sequence and the new sequence applied to some viaducts in Spain.
Diaz de Terán, Jose Ramon, Haach, Vladimir Guilherme, Jorquera Lucerga, Juan Jose, Turmo Coderque, José   +3 more
core   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Evidence of the selection of tidal streams by northern rock sole (Lepidopsetta polyxystra) for transport in the eastern Bering Sea [PDF]

, 2009
Depth data from archival tags on northern rock sole (Lepidopsetta polyxystra) were examined to assess whether fish used tidal currents to aid horizontal migration.
Nichol, Daniel G., Somerton, David A.
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Extended Material Recovery from Municipal Solid Waste Incinerator Bottom Ash Using Magnetic, Eddy Current, and Density Separations

Recycling
This research introduces an extended processing method for increasing the possibility of valorizing processed IBA (pr.IBA), which is currently only used as a construction material in landfill sites, considering its immense potential in valuable metal and
Ida Bagus Gede Sumbranang Adhiwiguna, Keshalinni Ramalingam, Karl-Heinz Becker, Alexander Khoury, Ragnar Warnecke, Rüdiger Deike   +5 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Self-protected electrodes limit field-emission current [PDF]

, 1975
One cathode includes array of square-shaped conductor columns. Columns are electrically interconnected by conducting plate on bottom. Each column provides field-emission current. Another cathode includes array of rodlike conductors.
Lees, W. L.
core   +1 more source

Theory versus experiments in heavy flavour production [PDF]

, 2001
I discuss the current status of the comparison between theoretical predictions and experimental data, relevant to the production of open charm and bottom quarks in photon-hadron and photon-photon collisions. I advocate the use of a formalism that matches
Frixione, S.
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Spatial Variability of the Hydrochemical Structure in Bottom Gravity Current in the Vema Fracture Zone

Russian Journal of Earth Sciences
The Vema Fracture Zone is located in the North Atlantic Ridge and extends along 11°N from 38 to 46°W. It is the main pathway for the spreading of Antarctic Bottom Water to the Northeast Atlantic.
Zuev Oleg, Seliverstova Anna M.
doaj   +1 more source