Results 81 to 90 of about 3,555,401 (304)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
A magnetic signature of bottom current erosion
Physics of the Earth and Planetary Interiors, 1988 Abstract To characterize the magnetic signal associated with bottom current erosion, we have conducted downcore measurements of magnetic texture and fabric in three cores containing known erosional hiatuses. Using biostratigraphic and magnetostratigraphic analysis, erosional hiatuses were identified for three cores from two current-dominated ...
Graduate School of Oceanography, University of Rhode Island, Narragansett, RI 02882 U.S.A. ( host institution ) +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Analysis of Current Status and Regulatory Promotion for Incineration Bottom Ash Recycling in Taiwan
Resources, 2020 Incineration is the most important technology for treating municipal solid waste (MSW) and industrial waste in Taiwan. Currently, there are 24 large-scale MSW incineration plants operated to generate about 1.2 million metric tons of residual ash (mostly ...
Chi-Hung Tsai +2 more
doaj +1 more source
High Energy Benthic Boundary Layer Experiment (HEBBLE): Preliminary program plan and conceptual design [PDF]
Deep sea processes of flow-sediment interaction, particularly the role of high energy ocean bottom current events in forming the seafloor topography, transporting material, and mixing the bottom of the water column are examined.
Frewing, K.
core +1 more source
Bottom-Tau Yukawa Unification in the Next-to-Minimal Supersymmetric Standard Model
, 1994 We discuss the unification of the bottom quark and tau lepton Yukawa couplings within the framework of the next-to-minimal supersymmetric standard model.
Ananthanarayan +20 more
core +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Journal of Marine Science and EngineeringAlong-slope bottom currents and down-slope (gravity-driven) turbidity currents coexist in the ocean and interact during their flow processes. The interaction between turbidity currents and bottom currents plays a crucial role in determining the lateral ...
Renqian Zhang +7 more
doaj +1 more source
Comparison of habitat-based indices of abundance with fishery-independent biomass estimates from bottom trawl surveys [PDF]
, 2012 Rockfish species are notoriously difficult to sample with multispecies bottom trawl survey methods. Typically, biomass estimates have high coefficients of variation and can fluctuate outside the bounds of biological reality from year to year.
Martin , Michael H. +1 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source