Results 81 to 90 of about 1,538,323 (350)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Spatial oxygen heterogeneity in a Hediste diversicolor irrigated burrow [PDF]
, 2011 The heterogeneity of oxygen distribution in a Hediste diversicolor burrow environment was investigated in a laboratory experiment using a 6-mm thick tank equipped with oxygen planar optodes. The twodimensional oxygen distribution in a complete burrow was
Cuny, Philippe +4 more
core +5 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Soil and Water Research, 2008 The influence was determined of the anthropo-pressure on the changes in the properties of the bottom sediments, with particular consideration given to the properties of humic acids formed in the sediments. The system of the Wdzydze Lakes consists of four
Joanna Cieslewicz +2 more
doaj +1 more source
Frontiers in Marine Science, 2023 Freshwater and sediments are transported from the Yellow River mouth downstream along the coast into Laizhou Bay under the northeasterly wind in winter. Numerical experiments indicate that sediment transport shows the tendency of convergence in the river
Xinyue Cheng +4 more
doaj +1 more source
Sedimentation and subsidence history of the Lomonosov Ridge [PDF]
, 2006 During the first scientific ocean drilling expedition to the Arctic Ocean (Arctic Coring Expedition [ACEX]; Integrated Ocean Drilling Program Expedition 302), four sites were drilled and cored atop the central part of the Lomonosov Ridge in the Arctic ...
Backman, J. +31 more
core +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Influence of shellfish farming activities on nitrification, nitrate reduction to ammonium and denitrification at the water-sediment interface of the Thau lagoon, France [PDF]
, 1997 The seasonal patterns of nitrification, denitrification and dissimilatory ammonium production (DAP) rates were studied in the sediment of 2 stations in the Thau lagoon (south of France).
Bianchi, Micheline +3 more
core +3 more sources
Scientific Reports, 2017 Microplastics are widely dispersed throughout the marine environment. An understanding of the distribution and accumulation of this form of pollution is crucial for gauging environmental risk.
Jake Martin +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source