Results 61 to 70 of about 2,658,042 (281)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Frequency-Domain Finite Element Modeling of Seismic Wave Propagation Under Different Boundary Conditions

Mathematics
Seismic wave propagation in complex terrains, especially in the presence of air layers, plays a crucial role in accurate subsurface imaging. However, the influence of different boundary conditions on seismic wave propagation characteristics has not been ...
Ying Zhang, Haiyang Liu, Shikun Dai, Herui Zhang   +3 more
doaj   +1 more source

Linear ODE with nonlocal boundary conditions and Green’s functions for such problems

Lietuvos Matematikos Rinkinys, 2019
In this article we investigate a formula for the Green’s function for the n-order linear differential equation with n additional conditions. We use this formula for calculating the Green’s function for problems with nonlocal boundary conditions.
Svetlana Roman, Artūras Štikonas
doaj   +1 more source

Numerical implementation of isolated horizon boundary conditions [PDF]

, 2006
We study the numerical implementation of a set of boundary conditions derived from the isolated horizon formalism, and which characterize a black hole whose horizon is in quasi-equilibrium.
A. Ashtekar, François Limousin, José Luis Jaramillo, Marcus Ansorg   +3 more
core   +4 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Existence of solutions to Sturm–Liouville boundary value problems

Electronic Journal of Qualitative Theory of Differential Equations
We study the solvability of Sturm–Liouville boundary value problems for $x''=f(t,x,x'), t\in(0,1)$. The nonlinearity can be defined on a bounded set and is required to be continuous on its subset.
Gabriela Mihaylova, Petio Kelevedjiev
doaj   +1 more source

Conformal boundary conditions from cutoff AdS3

Journal of High Energy Physics, 2021
We construct a particular flow in the space of 2D Euclidean QFTs on a torus, which we argue is dual to a class of solutions in 3D Euclidean gravity with conformal boundary conditions.
Evan Coleman, Vasudev Shyam
doaj   +1 more source

Periodic boundary conditions on the pseudosphere

, 2007
We provide a framework to build periodic boundary conditions on the pseudosphere (or hyperbolic plane), the infinite two-dimensional Riemannian space of constant negative curvature.
Alimohammadi M, Anglès d'Auriac J C, Baek S K, Beardon A F, Belo L R A Oliveira-Neto N M Moura-Melo W A Pereira A R Ercolessi E, Birrel N B, Comtet A, Coxeter H S M, Coxeter H S M, Doyon B, F Sausset, Frenkel D, G Tarjus, Giomi L Bowick M J, Hansen J P, Hasegawa I Sakaniwa Y Shima H, Hilbert D, Klein F, Kléman M, Landau D P, Magnus W, Nakahara M, Nechaev S, Nelson D R, Poincaré H, Rietman R, Sadoc J-F, Sausset F Tarjus G Viot P, Shima H, Shima H, Tarjus G, Ueda K Krcmar R Gendiar A Nishino T, Yuncken R   +32 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source