Results 71 to 80 of about 23,409 (291)
Учёные записки Казанского университета: Серия Физико-математические науки, 2018 A method for construction of solutions to the continuous approximate 2D Dirichlet and Neumann problems in the arbitrary simply-connected domain with a smooth boundary has been discussed.
A. El-Shenawy, E.A. Shirokova
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Solving the fluid flow problems with boundary domain integral method
, 2019 © 2019 IOP Publishing Ltd. The boundary-domain integral method with the analytical integrals over the individual boundaries and internal cells for the solving the boundary value problems of fluid flow problems is developed.
Mardanov R. +4 more
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Computational fluid dynamics by boundary-domain integral method
, 2012 A boundary-domain integral method for the solution of general transport phenomena incompressible fluid motion given by the Navier-Stokes equation set is presented. Velocity-vorticity formulation of the conservations is employed.
Kuhn, G. +2 more
core
Fluid flow simulation with an ▫$ℋ^2$▫ -accelerated boundary-domain integral method
The development of new numerical methods for fluid flow simulations is challenging but such tools may help to understand flow problems better. Here, the Boundary-Domain Integral Method is applied to simulate laminar fluid flow governed by a dimensionless
Tibaut, Jan, Ravnik, Jure, Schanz, M
core +2 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Fast boundary-domain integral method for simulation of transport phenomena in fluids
, 2019 V doktorski disertaciji predstavljamo hitro robno-območno integralsko metodo, ki smo jo uporabili za reševanje prenosnih pojavov v tekočini. Hitra robno-območna integralska metoda izhaja iz robno-območne integralske metode.
Tibaut, Jan
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source