Results 41 to 50 of about 219,208 (264)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Chemical Characteristics and Potential Sources of PM2.5 in Shahe City during Severe Haze Pollution Episodes in the Winter

Aerosol and Air Quality Research, 2020
In recent years, North China has suffered from severe air pollution. Hence, this study performed a comprehensive field experiment during Dec. 2017 in Shahe (114.5°N, 36.85°E), a typical industrial city in this region that is characterized by intensive ...
Xiaoyong Liu, Xiaole Pan, Zifa Wang, Hong He, Dawei Wang, Hang Liu, Yu Tian, Weiling Xiang, Jie Li   +8 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Quantitative study on the water vapor transport characteristics of an extreme precipitation event in North China

Atmospheric Science Letters
North China experienced an extreme precipitation event from July 29 to August 1, 2023 (i.e., the “23.7” event) causing severe floods, significant infrastructure damage and multiple fatalities.
Xiaofan Li, Yufei Chang, Changwen Yu, Zhiqiang Gong, Yunhao Li, Zhongjie Zhang, Shaojing Che   +6 more
doaj   +1 more source

Effects of Regional Transport on Haze in the North China Plain: Transport of Precursors or Secondary Inorganic Aerosols

Geophysical Research Letters, 2020
Most previous studies treat regional transport of aerosols as a whole, without distinguishing the transport of secondary aerosols and that of their precursors.
Huiyun Du, Jie Li, Zifa Wang, Xu Dao, Song Guo, Lingling Wang, Shuangliang Ma, Jianbin Wu, Wenyi Yang, Xueshun Chen, Yele Sun   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The monsoon effect on energy and carbon exchange processes over a highland lake in the southwest of China [PDF]

Atmospheric Chemistry and Physics, 2018
Erhai Lake is a subtropical highland shallow lake on the southeast margin of the Tibetan Plateau, which is influenced by both South Asian and East Asian summer monsoons.
Q. Du, H. Liu, H. Liu, L. Xu, Y. Liu, Y. Liu, L. Wang   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Using a modified DNDC biogeochemical model to optimize field management of a multi-crop (cotton, wheat, and maize) system: a site-scale case study in northern China [PDF]

Biogeosciences, 2019
It is still a severe challenge to optimize the field management practices for a multi-crop system when simultaneously aiming at yield sustainability and minimum negative impacts on climate as well as atmosphere and water quality.
W. Zhang, C. Liu, X. Zheng, X. Zheng, K. Wang, F. Cui, F. Cui, R. Wang, S. Li, S. Li, Z. Yao, J. Zhu   +11 more
doaj   +1 more source