Results 41 to 50 of about 216,993 (266)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Impacts of additional HONO sources on O3 and PM2.5 chemical coupling and control strategies in the Beijing–Tianjin–Hebei region of China [PDF]

Tellus: Series B, Chemical and Physical Meteorology, 2015
The objective of this work is to examine the impacts of additional HONO sources on the chemical interaction between ozone (O3) and particulate matter with a diameter≤2.5 µm (PM2.5). Three additional HONO sources, i.e.
Ying Li, Junling An, Mizuo Kajino, Ismail Gultepe, Yong Chen, Tao Song, Jinyuan Xin   +6 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Effects of Regional Transport on Haze in the North China Plain: Transport of Precursors or Secondary Inorganic Aerosols

Geophysical Research Letters, 2020
Most previous studies treat regional transport of aerosols as a whole, without distinguishing the transport of secondary aerosols and that of their precursors.
Huiyun Du, Jie Li, Zifa Wang, Xu Dao, Song Guo, Lingling Wang, Shuangliang Ma, Jianbin Wu, Wenyi Yang, Xueshun Chen, Yele Sun   +10 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Quantitative study on the water vapor transport characteristics of an extreme precipitation event in North China

Atmospheric Science Letters
North China experienced an extreme precipitation event from July 29 to August 1, 2023 (i.e., the “23.7” event) causing severe floods, significant infrastructure damage and multiple fatalities.
Xiaofan Li, Yufei Chang, Changwen Yu, Zhiqiang Gong, Yunhao Li, Zhongjie Zhang, Shaojing Che   +6 more
doaj   +1 more source

Chemical Characteristics and Potential Sources of PM2.5 in Shahe City during Severe Haze Pollution Episodes in the Winter

Aerosol and Air Quality Research, 2020
In recent years, North China has suffered from severe air pollution. Hence, this study performed a comprehensive field experiment during Dec. 2017 in Shahe (114.5°N, 36.85°E), a typical industrial city in this region that is characterized by intensive ...
Xiaoyong Liu, Xiaole Pan, Zifa Wang, Hong He, Dawei Wang, Hang Liu, Yu Tian, Weiling Xiang, Jie Li   +8 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Using a modified DNDC biogeochemical model to optimize field management of a multi-crop (cotton, wheat, and maize) system: a site-scale case study in northern China [PDF]

Biogeosciences, 2019
It is still a severe challenge to optimize the field management practices for a multi-crop system when simultaneously aiming at yield sustainability and minimum negative impacts on climate as well as atmosphere and water quality.
W. Zhang, C. Liu, X. Zheng, X. Zheng, K. Wang, F. Cui, F. Cui, R. Wang, S. Li, S. Li, Z. Yao, J. Zhu   +11 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source