Results 61 to 70 of about 6,770,878 (333)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Supersonic Shear Instabilities in Astrophysical Boundary Layers
, 2011 Disk accretion onto weakly magnetized astrophysical objects often proceeds via a boundary layer that forms near the object's surface, in which the rotation speed of the accreted gas changes rapidly.
Belyaev, Mikhail, Rafikov, Roman
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
On geometry effects in Rayleigh-Benard convection [PDF]
, 2002 Various recent experiments hint at a geometry dependence of scaling relations in Rayleigh-B\'enard convection. Aspect ratio and shape dependences have been found. In this paper a mechanism is offered which can account for such dependences. It is based on
Grossmann, Siegfried, Lohse, Detlef
core +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Geostrophic convective turbulence: The effect of boundary layers [PDF]
, 2015 Rayleigh--B\'enard (RB) convection, the flow in a fluid layer heated from below and cooled from above, is used to analyze the transition to the geostrophic regime of thermal convection. In the geostrophic regime, which is of direct relevance to most geo-
Kunnen, Rudie P. J. +4 more
core +4 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Boundary layers for transmission problems with singularities
Electronic Journal of Differential Equations, 2006 We study two-dimensional transmission problems for the Laplace operator for two diffusion coefficients. We describe the boundary layers of this problem and show that the layers appear only in the part where the coefficient is large.
Abderrahman Maghnouji, Serge Nicaise
doaj
Boundary towers of layers for some supercritical problems [PDF]
, 2013 We show that in some suitable torus-like domains D some supercritical elliptic problems have an arbitrary large number of sign-changing solutions with alternate positive and negative layers which concentrate at different rates along a k-dimensional ...
Kim, Seunghyeok, Pistoia, Angela
core +1 more source