Results 131 to 140 of about 3,207,541 (303)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Boundary objects as a starting point for reflective learning in vocational education and training classrooms

Nordic Journal of Vocational Education and Training
This article examines the use of thematic assignments developed by vocational education and training (VET) teachers in Norway that focus on students’ work practices.
Monika Øgård
doaj   +1 more source

Making the anaesthetised animal into a boundary object: an analysis of the 1875 Royal Commission on Vivisection. [PDF]

Hist Philos Life Sci, 2020
Holmes T, Friese C.
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Deliberating justice in food systems transformation pathways: a transdisciplinary approach applied in Finland

Environmental Research: Food Systems
The need for transformation in food systems is acknowledged broadly. Persisting lock-ins and systemic interactions require research going beyond disciplinary approaches.
Minna Kaljonen, Theresa Tribaldos, Teea Kortetmäki, Jyrki Niemi, Suvi Huttunen, Laura Paalanen, Jani Salminen, Riikka Aro, Luciene Burlandy, Mari Heikkinen, Ellen Huan-Niemi, Tommi Härkänen, Xavier Irz, Kaisa Karttunen, Marja Knuuttila, Venla Kyttä, Heikki Lehtonen, Annika Lonkila, Anu Lähteenmäki-Uutela, Renato S Maluf, Ari Paloviita, Antti Puupponen, Merja Saarinen, Laura Sares-Jäske, Hannu Savolainen, Marjatta Selänniemi, Heli Tapanainen, Marjaana Toivonen, Anni Turunen, Henri Virkkunen, Henrik Wejberg   +30 more
doaj   +1 more source

Riparian systems as boundary objects in sustainable water transition

Frontiers in Human Dynamics
This paper contributes to debates on sustainable transitions in urban water management by proposing a relational and governance-oriented understanding of river-city interactions.
Radamés Villagómez-Reséndiz, Radamés Villagómez-Reséndiz, Radamés Villagómez-Reséndiz, Olivier Dangles, Olivier Dangles, Olivier Dangles, Olivier Dangles   +6 more
doaj   +1 more source

Operation and Maintenance of the Jointly-Financed Works for Solution of the Lower Rio Grande Salinity Problem

, 2000
No ...
International Boundary and Water Commission
core  

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source