Results 21 to 30 of about 149,442,687 (225)
The tri-harmonic Neumann problem
Қарағанды университетінің хабаршысы. Математика сериясы, 2018 In this article investigated the tri-harmonic Neumann function for the unit dics. For harmonics functions the Neumann’s boundary problem is well studied and solved under certain conditions through Neumann’s function, sometimes it is also called Green’s ...
S. Burgumbayeva
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AxiomsWe consider a two-step numerical approach for solving parabolic initial boundary value problems in 3D simply connected smooth regions. The method uses the Laplace transform in time, reducing the problem to a set of independent stationary boundary value ...
Roman Chapko, Svyatoslav Lavryk
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Positive solutions of nonlinear fourth-order boundary-value problems with local and non-local boundary conditions [PDF]
, 2008 We establish new existence results for multiple positive solutions of fourth-order nonlinear equations which model deflections of an elastic beam. We consider the widely studied boundary conditions corresponding to clamped and hinged ends and many non ...
J. R. L. Webb +5 more
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上海师范大学学报. 自然科学版, 2016 The main purpose is to accomplish the existence and instability of infinitely many multiple standing pulse solutions of a nonlinear system of reaction diffusion equations and some nonlinear scalar reaction diffusionequations.
ZHANG Linghai
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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