The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source
Delay-driven dynamics in a host-vector model of canine Chagas disease. [PDF]
Raza A +4 more
europepmc +1 more source
Boundedness and periodicity of solutions of a certain system of third-order non-linear differential equations [PDF]
J. O. C. Ezeilo, H. O. Tẹjumọla
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Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Stochastic modeling of pneumonia transmission dynamics and implications for public health control. [PDF]
Raza A +5 more
europepmc +1 more source
$L^p$-boundedness properties for some harmonic analysis operators defined by resolvents for a Laplacian with drift in Euclidean spaces [PDF]
Jorge J. Betancor +2 more
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Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
A Caputo fractional-order SEIHRD model for Ebola: theoretical analysis, sensitivity, bifurcation, and numerical simulations. [PDF]
Malathy R, Krishnan GSS, Loganathan K.
europepmc +1 more source
On the Total Stability and the Total Boundedness of the Perturbed Systems
Shoichi Seino, Miki Kudo, Masamichi Aso
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