Results 161 to 170 of about 6,910,975 (305)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Screening to Assess Psychosocial Follow-Up Needs in Pediatric Oncology (Self- and Parent-Report)

Der NPO-11 dient als Screening zur Einschätzung des psychosozialen Nachsorgebedarfs in der pädiatrischen Onkologie im Selbst- und Elternbericht. Anhand von Expertenangaben wurden jeweils 11 Items für die Nachsorgebereiche Progredienzangst, Traurigkeit ...
Kamm-Thonwart, R., Hoffmann, R., Kulisch, L., Schepper, F., Jäschke, Y., Martini, J., Herrmann, J., Herzog, K., Graf Einsiedel, H.   +8 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

CASQ. Coping Across Situations Questionnaire

Der CASQ erfasst das individuelle Bewältigungsverhalten von Jugendlichen in belastenden Situationen. 20 Bewältigungsstrategien in acht altersspezifischen Problembereichen werden den drei Subskalen "Aktive Bewältigung", "Internale Bewältigung" und ...
Seiffge-Krenke, I.
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Tractor Testing; Belt Power Test; Leroi Centaur

, 1948
1948. Belt test no. 402. Centaur KV 48. with G. Olson, W. McPhail, Billy Bryan. Centaur KV-48 in the tractor test lab. A belt runs from the tractor pulley to the dynamometer in the adjacent room. Gordon Olson mans the dyno controls, W.
Nebraska Tractor Test Laboratory
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Environment geometry alters sequential route learning and its integration into cognitive maps. [PDF]

Nat Commun
Long J, Herrera E, Li Y, Oliveira F, Ahmed R, Hussain S, Rivera C, Liquori K, Brown T.   +8 more
europepmc   +1 more source

Tractor Testing; Belt Power Test; Caterpillar

, 1940
Text states: "1940. Checking engine R.P.M. during test no. 357." The Caterpillar D-8 is shown from the rear, where the belt pulley is located. A test engineer is measuring the belt pulley RPM with a handheld Tachometer (an RPM counter) touching the ...
Nebraska Tractor Test Laboratory
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source