Results 21 to 30 of about 16,238 (186)

« Et encourt sont les dictes forches en la dicte place toutes droictes… ». La guerre des gibets dans l’État bourguignon naissant (Franche-Comté, 1380-1400)

open access: yesCriminocorpus, 2015
Just as the signboards that physically mark the territory in the Prince’name, the gallows show the progression of his sovereign justice and his political authority.
Michelle Bubenicek
doaj   +1 more source

N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death. [PDF]

open access: yes, 2017
APO2L/TRAIL (TNF-related apoptosis-inducing ligand) induces death of tumor cells through two agonist receptors, TRAIL-R1 and TRAIL-R2. We demonstrate here that N-linked glycosylation (N-glyc) plays also an important regulatory role for TRAIL-R1-mediated ...
A Ashkenazi   +59 more
core   +3 more sources

Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

open access: yesNature Communications, 2018
Lipid droplets (LD) accumulation correlates with colorectal cancer (CRC) relapse. Here the authors show that chemotherapy induces LD synthesis via acyltransferase LPCAT2 which, in turn, promotes chemoresistance via LD accumulation both in vitro and in ...
Alexia Karen Cotte   +11 more
doaj   +1 more source

Evidence of biological activity of Mentha species extracts on apoptotic and autophagic targets on murine RAW264.7 and human U937 monocytic cells

open access: yesPharmaceutical Biology, 2017
Context: Mints (Lamiaceae) are used as traditional remedies for the treatment of several diseases. Their extracts are recognized as anti-inflammatory compounds. Objective: This study characterized the cytotoxic effects of Mentha spicata L.
Fatiha Brahmi   +10 more
doaj   +1 more source

Effects of local cryotherapy on systemic endothelial activation, dysfunction, and vascular inflammation in adjuvant-induced arthritis (AIA) rats

open access: yesArthritis Research & Therapy, 2022
Aim This study explored the systemic vascular effects of local cryotherapy with a focus on endothelial changes and arterial inflammation in the model of rat adjuvant-induced arthritis (AIA). Methods Cryotherapy was applied twice a day on hind paws of AIA
C. Peyronnel   +8 more
doaj   +1 more source

Recent insights into the implications of metabolism in plasmacytoid dendritic cell innate functions: Potential ways to control these functions [version 2; referees: 1 approved, 2 approved with reservations]

open access: yesF1000Research, 2017
There are more and more data concerning the role of cellular metabolism in innate immune cells, such as macrophages or conventional dendritic cells. However, few data are available currently concerning plasmacytoid dendritic cells (PDC), another type of ...
Philippe Saas   +3 more
doaj   +1 more source

HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias

open access: yesBlood Cancer Journal, 2021
T-cell and B-cell acute lymphoblastic leukemias (T-ALL, B-ALL) are aggressive hematological malignancies characterized by an accumulation of immature T- or B-cells.
Rony Mshaik   +13 more
doaj   +1 more source

Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation

open access: yesCell Reports, 2017
Sirtuin-1 deacetylates proteins and has emerged as a critical regulator of different cellular processes, particularly inflammation. Basal SIRT1 activity was previously found to limit Th9 and enhance Th17 differentiation in mice, but the effect of ...
Emeric Limagne   +13 more
doaj   +1 more source

Existence and Stability of standing waves for supercritical NLS with a Partial Confinement [PDF]

open access: yes, 2016
We prove the existence of orbitally stable ground states to NLS with a partial confinement together with qualitative and symmetry properties. This result is obtained for nonlinearities which are $L^2$-supercritical, in particular we cover the physically ...
Bellazzini, J.   +3 more
core   +2 more sources

Wheat Rhizosphere Microbiota Respond to Changes in Plant Genotype, Chemical Inputs, and Plant Phenotypic Plasticity

open access: yesFrontiers in Ecology and Evolution, 2022
Modern wheat varieties that were selected since the Green Revolution are generally grown with synthetic chemical inputs, and ancient varieties released before1960 without.
Samuel Jacquiod   +6 more
doaj   +1 more source

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