Results 21 to 30 of about 330,483 (130)
Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV
Hepatology, Volume 76, Issue 5, Page 1506-1519, November 2022., 2022 Abstract Background and Aims Lack of tractable immunocompetent animal models amenable to robust experimental challenge impedes vaccine efforts for HCV. Infection with rodent hepacivirus from Rattus norvegicus (RHV‐rn1) in rats shares HCV‐defining characteristics, including liver tropism, chronicity, and pathology.
Raphael Wolfisberg +12 more
wiley +1 more source
Research progress on pharmacological effects and new dosage forms of baicalin
Veterinary Medicine and Science, Volume 8, Issue 6, Page 2773-2784, November 2022., 2022 This current review offers a comprehensive report on the anti‐inflammatory, anti‐oxidant, anti‐viral and anti‐tumor of baicalin, the application of new dosage forms of baicalin to the development progress which would be an effective medicine for clinical application.
Minglong Bao +6 more
wiley +1 more source
Hepatology, Volume 76, Issue 4, Page 1190-1202, October 2022., 2022 Abstract Background and Aims A prophylactic vaccine targeting multiple HCV genotypes (gt) is urgently required to meet World Health Organization elimination targets. Neutralizing antibodies (nAbs) and CD4+ and CD8+ T cells are associated with spontaneous clearance of HCV, and each may contribute to protective immunity.
Timothy Donnison +8 more
wiley +1 more source
Natural co‐infection of divergent hepatitis B and C virus homologues in carnivores
Transboundary and Emerging Diseases, Volume 69, Issue 2, Page 195-203, March 2022., 2022 Abstract In humans, co‐infection of hepatitis B and C viruses (HBV, HCV) is common and aggravates disease outcome. Infection‐mediated disease aggravation is poorly understood, partly due to lack of suitable animal models. Carnivores are understudied for hepatitis virus homologues.
Wendy K. Jo +14 more
wiley +1 more source
Plant Biotechnology Journal, Volume 19, Issue 10, Page 2027-2039, October 2021., 2021 Summary Chronic infection with hepatitis C virus (HCV) remains a leading cause of liver‐related pathologies and a global health problem, currently affecting more than 71 million people worldwide. The development of a prophylactic vaccine is much needed to complement the effective antiviral treatment available and achieve HCV eradication.
Mihaela‐Olivia Dobrica +16 more
wiley +1 more source
Hepatology, Volume 74, Issue 3, Page 1148-1163, September 2021., 2021 Background and Aims Equine hepacivirus (EqHV) is phylogenetically the closest relative of HCV and shares genome organization, hepatotropism, transient or persistent infection outcome, and the ability to cause hepatitis. Thus, EqHV studies are important to understand equine liver disease and further as an outbred surrogate animal model for HCV ...
Joy E. Tomlinson +16 more
wiley +1 more source
Equine Veterinary Journal, Volume 53, Issue 5, Page 886-894, September 2021., 2021 Abstract Equine parvovirus hepatitis (EqPV‐H) was first described in 2018 in a fatal case of Theiler's disease which followed the administration of an equine‐origin biological product. The virus has since been frequently identified in serum and liver tissue of horses affected by Theiler's disease—an acute, severe hepatitis characterised by fulminant ...
Anna Sophie Ramsauer +2 more
wiley +1 more source
Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry
Cell Reports, 2013 Enveloped viruses have developed various adroit mechanisms to invade their host cells. This process requires one or more viral envelope glycoprotein to achieve cell attachment and membrane fusion.
Kamel El Omari +4 more
doaj +1 more source
Morphology and Molecular Composition of Purified Bovine Viral Diarrhea Virus Envelope.
PLoS Pathogens, 2016 The family Flaviviridae includes viruses that have different virion structures and morphogenesis mechanisms. Most cellular and molecular studies have been so far performed with viruses of the Hepacivirus and Flavivirus genera.
Nathalie Callens +10 more
doaj +1 more source
Viruses, 2018 In situ hybridization (ISH) is a technique to determine potential correlations between viruses and lesions. The aim of the study was to compare ISH techniques for the detection of various viruses in different tissues.
Vanessa M. Pfankuche +14 more
doaj +1 more source