Results 121 to 130 of about 93,539 (271)

Translation of bovine leukemia virus virion RNAs in heterologous protein-synthesizing systems [PDF]

, 1979
Jacques Ghysdael, R. Kettmann, Arsène Burny   +2 more
openalex   +1 more source

GREM1 deficiency induced bone marrow adipose niche promotes B‐cell acute lymphoblastic leukemia disease progression

International Journal of Cancer, Volume 157, Issue 3, Page 559-572, 1 August 2025.
What's new? Too often, children treated for B‐cell acute lymphocytic leukemia (B‐ALL) experience relapse. Here, the authors investigate the role of dyslipidemia in leukemia progression. Higher adipogenicity in bone marrow mesenchymal stem cells, and increased triglyceride accumulation, are associated with higher risk of death.
Lili Song, Rui Zhang, Liya Pan, Qiang Mi, Yi Yang, Xiang Wang, Yani Ma, Shuhong Shen, Benshang Li, Yanxin Li, Li Hong   +10 more
wiley   +1 more source

Glucocorticoid effects on peripheral blood lymphocytes in cows infected with bovine leukemia virus [PDF]

, 1979
JC Bloom, SJ Kenyon, TG Gabuzda
openalex   +1 more source

Delineation of monocytic and early‐stage myeloid‐derived suppressor cells in the peripheral blood of patients with hepatocarcinoma

International Journal of Cancer, Volume 156, Issue 12, Page 2416-2428, 15 June 2025.
What's new? In hepatocellular carcinoma, expanded myeloid‐derived suppressor cells (MDSC) relate to aggressiveness and poor prognosis. A global analysis of the different MDSC subsets in hepatocellular carcinoma is, however, missing. In this study, all three subsets of M‐MDSC, PMN‐MDSC, and eMDSC, together with arginase 1 activity, were significantly ...
Marta Chivite‐Lacaba, Iago Justo, Alberto Utrero‐Rico, Oscar Caso, Cecilia González‐Cuadrado, Manuel J. Del Rey, Rocio Laguna‐Goya, Javier Arroyo‐Ródenas, Ángel Alfocea‐Molina, Carlota C. Ruigómez‐Martín, Manuel Serrano, Lorena Pascual‐Palacios, María Esther Mancebo, Estela Paz‐Artal   +13 more
wiley   +1 more source

KDM6A Deficiency Induces Myeloid Bias and Promotes CMML‐Like Disease Through JAK/STAT3 Activation by Repressing SOCS3

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Lysine demethylase 6A (KDM6A), an epigenetic regulator expressed in hematopoietic stem and progenitor cells (HSPCs), plays a critical role in hematopoietic homeostasis. Deficiency of KDM6A induces myeloid lineage skewing and drives the development of a chronic myelomonocytic leukemia (CMML)‐like disease.
Huiqiao Chen, Shufen Wang, Ruoyu Dong, Pinhui Yu, Tianyu Li, Liangning Hu, Mowang Wang, Zijun Qian, Hongyu Zhou, Xiaoyan Yue, Limengmeng Wang, Haowen Xiao   +11 more
wiley   +1 more source

Gene therapy of malignant glioma with retroviral vectors and tumor-infiltrating progenitor cells [PDF]

, 2008
Gene therapy as a therapeutic strategy in the treatment of human gliomas is limited by the efficacy of gene transfer and intratumoral distribution of viral vectors.
Miletic, Hrvoje
core  

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun, Yangyang Shi, Chen Yan, Shunmin Wang, Linhui Han, Fudong Li, Ximing Xu, Yuan Wang, Jingchuan Sun, Zijian Kang, Jiangang Shi   +10 more
wiley   +1 more source

Hamster leukemia virus: lack of endogenous DNA synthesis and unique structure of its DNA polymerase [PDF]

, 1974
Infectious hamster leukemia virus (HaLV) contains a DNA polymerase different from those of murine and avian viruses. No endogenous reaction directed by the 60 to 70S RNA of HaLV could be demonstrated in detergenttreated HaLV virions, nor could the ...
Baltimore, David, Fan, Hung, Meuth, Nora L., Verma, Inder M.   +3 more
core  

PRMT5 Promotes Pancreatic Cancer Tumorigenesis via Positive PRMT5/C‐Myc Feedback Loop

MedComm, Volume 6, Issue 6, June 2025.
By forming a positive feedback loop with c‐Myc, PRMT5 promoted the pancreatic cancer tumorigenesis. Inactivation of PRMT5 with small molecular inhibitors led to suppressed proliferation, colony formation, enhanced apoptosis, and cell cycle arrest. Targeting PRMT5 exhibited promising therapeutic effect for pancreatic cancer . ABSTRACT The oncogenic role
Fan Yang, Ping Song, Zhaofeng Xiao, Renyi Su, Xin Fang, Yichao Wu, Xiao Xu, Kai Wang   +7 more
wiley   +1 more source

An optimised Bcl‐3 inhibitor for melanoma treatment

British Journal of Pharmacology, Volume 182, Issue 11, Page 2426-2446, June 2025.
Abstract Background and Purpose Malignant melanoma is the most lethal form of skin cancer, characterised by a poor survival rate. One of the key factors driving the aggressive growth of melanoma cells is the elevated expression of the proto‐oncogene Bcl‐3. This study aims to optimise, evaluate and characterise a second‐generation Bcl‐3 inhibitor, using
Karunakar Saamarthy, Renée Daams, Wondossen Sime, Cecilia Persson, Eduard Chygorin, Kristofer Ahlqvist, Susan Evans‐Axelsson, Daniel Strand, Ramin Massoumi   +8 more
wiley   +1 more source