Ultra-high resolution X-ray structure of orthorhombic bovine pancreatic Ribonuclease A at 100K [PDF]
BMC Chemistry, 2023 The crystal structure of orthorhombic Bovine Pancreatic Ribonuclease A has been determined to 0.85 Å resolution using low temperature, 100 K, synchrotron X-ray data collected at 16000 keV (λ = 0.77 Å). This is the first ultra-high-resolution structure of
David R. Lisgarten +9 more
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Bovine pancreatic ribonuclease: fifty years of the first enzymatic reaction mechanism. [PDF]
Biochemistry, 2011 Cuchillo CM, Nogués MV, Raines RT.
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A phosphate-binding subsite in bovine pancreatic ribonuclease A can be converted into a very efficient catalytic site. [PDF]
Protein Sci, 2007 Moussaoui M, Cuchillo CM, Nogués MV.
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Molecular dynamics simulation of bovine pancreatic ribonuclease A-CpA and transition state-like complexes. [PDF]
J Phys Chem B, 2010 Formoso E, Matxain JM, Lopez X, York DM.
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Production of ovine Pancreatic Ribonuclease and investigation of enzyme characteristics [PDF]
پژوهشهای علوم دامی ایران, 2021 Introduction Obviously, the recent decades strategy in cancer therapy, anticancer drug discovery and drug improvement is to characterize, distinguish and validate the most promising cancer-related molecular targets to which new drugs can be designed. The
mahsa Zabetian +3 more
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Kinetic and thermodynamic analysis of the conformational folding process of SS-reduced bovine pancreatic ribonuclease A using a selenoxide reagent with high oxidizing ability. [PDF]
FEBS Open Bio, 2012 Arai K, Kumakura F, Iwaoka M.
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Ribonucleases as potential therapeutic agents [PDF]
مجله بیوتکنولوژی کشاورزی, 2021 Objective Due to high cytotoxicity effect, ribonucleases (RNases) are known as pharmacological agents with therapeutic potential. The high potential of these enzymes in the destruction of RNA strand and their other substrates and subsequently, cell ...
Masoume Vakili-Azghandi +3 more
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Engineering and production of recombinant bovine pancreatic ribonuclease enzyme (RNase A) as a potential therapeutic [PDF]
مجله بیوتکنولوژی کشاورزی, 2021 Objective Immunotoxins are one of the most promising ways in therapeutic fields, specially cancer therapy which have a unique toxin-antibody structure, and kill the cancer cell by passing through the cell membrane and entering the target cell.
Masoume Vakili-Azghandi +3 more
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PEGylated gold nanoparticles-ribonuclease induced oxidative stress and apoptosis in colorectal cancer cells [PDF]
BioImpacts, 2020 Introduction: Currently, drug-induced reactive oxygen species (ROS) mediating apoptosis pathway have extensively been investigated in designing effective strategies for colorectal cancer (CRC) chemotherapy.
Mostafa Akbarzadeh Khiavi +7 more
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Bovine Pancreatic RNase A: An Insight into the Mechanism of Antitumor Activity In Vitro and In Vivo
Pharmaceutics, 2022 In this investigation, we extensively studied the mechanism of antitumor activity of bovine pancreatic RNase A. Using confocal microscopy, we show that after RNase A penetration into HeLa and B16 cells, a part of the enzyme remains unbound with the ...
Islam Saber Ead Mohamed +6 more
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