Progress in RNA‐Targeted Therapeutics for Human Diseases
MedComm, Volume 7, Issue 2, February 2026.RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang +10 more
wiley +1 more source
Aging Cell, Volume 25, Issue 2, February 2026.mBEDOs: a scalable platform for modeling urothelial aging. mBEDOs derived from aged mouse bladders capture essential molecular and cellular features of urothelial aging and provide a versatile system for high‐throughput metabolic profiling, therapeutic screening via metabolite supplementation, age‐ and sex‐based analyses, infection modeling, and immune–
Adwaita R. Parab +8 more
wiley +1 more source
Selective Deamidation and Enzymatic Methylation of Seminal Ribonuclease [PDF]
, 1986 Isoenzymatic forms alfa2, alfa-beta, and beta2 of bovine seminal ribonuclease are generated by the transformation of beta-type into alfa-type subunit through deamidation of a single amide group. The residue involved in this selective deamidation has been
D'ALESSIO, GIUSEPPE +2 more
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The surface accessibility of α-bungarotoxin monitored by a novel paramagnetic probe [PDF]
, 2011 The surface accessibility of {alpha}-bungarotoxin has been investigated by using Gd2L7, a newly designed paramagnetic NMR probe. Signal attenuations induced by Gd2L7 on {alpha}-bungarotoxin C{alpha}H peaks of 1H-13C HSQC spectra have been analyzed and ...
Bernini, A +7 more
core
Conformational‐transitions of bovine pancreatic ribonuclease S‐peptide [PDF]
FEBS Letters, 1968 Tamburro, A.M. +5 more
openaire +2 more sources
Comparison of protein structures determined by NMR in solution and by X-ray diffraction in single crystals [PDF]
, 2017 Following the first determinations of protein structures in the late 1950s and the early 1960s (see for example Kendrew et al. 1960; Perutz, 1964), the three-dimensional structures of several hundred proteins have been elucidated by X-ray diffraction on ...
Billeter, Martin
core
Inactive and temperature-sensitive folding mutants of aldehyde dehydrogenase of Escherichia coli [PDF]
, 2010 Aldehyde dehydrogenase, encoded by the aldA gene in Escherichia coli, is inactive in nitrosoguanidine induced mutant strain ECL40 and temperature-sensitive in spontaneous mutant strain JA104.
Ana Enjuanes, Ana Limón, Juan Aguilar
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Differential distribution of rna and protein in the ribosomal fractions of escherichia coli [PDF]
Differential distribution of RNA and protein in ribosomal fractions of Escherichia ...
Raacke, I. D.
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Diversity and Dynamics of Indigenous \u3cem\u3eRhizobium japonicum\u3c/em\u3e Populations [PDF]
, 1980 A simple method, based upon the separation of cellular proteins by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis, has been devised for distinguishing between isolates of Rhizobium japonicum.
Brill, Winston J., Noel, K. Dale
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Synthesis and Nucleophilic Reactions of Bifunctional Thiourea S,S,S-Trioxides [PDF]
, 1989 The synthesis of bifunctional thioureas and the corresponding thiourea S,S,S-trioxides has been examined. Two methods for the synthesis of the bisthioureas were employed. One involved the treatment of a diamine with silicon tetraisothiocyanate in benzene.
Webb \u2789, Dan
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