Results 141 to 150 of about 172,055 (278)

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Establishment of a duplex TaqMan-based real time RT-PCR assay for simultaneous detection of BRSV and BVDV

Frontiers in Veterinary Science
Bovine respiratory disease complex (BRDC) represents a global acute respiratory condition that imposes substantial economic burdens on the cattle industry due to its high morbidity and mortality rates.
Fuxing Hao, Jinping Fu, Jun Chen, Daoxian Zhu, Bingyan Cai, Yuxin Li, Chuanmin Liu   +6 more
doaj   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

SEROPREVALENCE AND RISK FACTORS OF BOVINE RESPIRATORY SYNCYTIAL VIRUS IN DAIRY AND BEEF CATTLE HERDS IN REPUBLIC OF BULGARIA

Trakia Journal of Sciences
Bovine respiratory syncytial virus (BRSV) is one of the important causative agents of Bovine respiratory disease complex (BRDC) in cattle all over the world.
P. Marutsov, B. Boneva-Marutsova
doaj   +1 more source

Bovine Respiratory Disease Complex – A Review

International Journal of Current Microbiology and Applied Sciences, 2018
Praveen Kumar, Anup Yadav, Lo kesh, Rajendra Yadav, Pankaj Kumar, R.P. Diwakar   +5 more
openaire   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

An assessment of opportunities to dissect host genetic variation in resistance to infectious diseases in livestock [PDF]

, 2009
Adzhubei, Ait-Ali, Al-Haddawi, Asif, Atapattu, Bacon, Bacon, Bakker, Barillet, Barrow, Barrow, Bishop, Boyd, Briles, Brisbin, Bumstead, Bumstead, Bumstead, Bumstead, Bumstead, Callaway, Cao, Carlén, Caverly, Cheng, Chiodini, Cole, Cutlip, Dassanayake, Davies, Diez-Tascon, Dileepan, Dominik, E. Giuffra, Ewart, Flori, Fragkou, Friars, G. Davies, Gasbarre, Gauly, Gavora, Gibbons, Gonda, Gonda, Gordon, Gougoulis, Guy, Gyles, Haesebrouck, Hala, Halbur, Hassan, Hayes, Heringstad, Hickford, Houston, Hu, Jackwood, Jensen, Jiao, Juul-Madsen, Kaiser, Kaufman, Keane, Khatkar, Koets, Kramer, Lamont, Lavi, Legarra, Lewis, Liu, Liu, Longenecker, Lund, Lundeheim, Lundeheim, MacKinnon, Mackintosh, Malek, Mariani, Martin, Mavrogianni, Mays, Meijerink, Minion, Mirsky, Moen, Mortensen, Muggli-Cockett, Nakajima, Nieuwhof, Niewold, Noormohammadi, Opriessnig, Peng, Permin, Perry, Petry, Petry, Pinard-van der Laan, Pinard-van der Laan, Purchase, Python, Raadsma, Reiner, Rise, Roehrig, Ruiz, Rupp, S. Genini, S.C. Bishop, Sacco, Schmidt, Schou, Sellwood, Smith, Snowder, Snowder, Sonstegard, Tilquin, Tsai, Tuggle, Uthe, Uthe, Vallejo, Van Diemen, Van Dorp, Van Hemert, Van Hemert, Van Reeth, Vincent, Vincent, Von Schalburg, Vögeli, Wang, Wetten, Williams, Williams, Witter, Yonash, Yonash, Yoo, Young, Yunis, Zhang, Zhu   +147 more
core   +1 more source

DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy

Advanced Science, EarlyView.
Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi, Fei Li, Heng Jiang, Lingling Gu, Mengjie Sun, Kunyu Lu, Pianpian Liu, Ruyue Xie, Wenqiang Ma, Meijuan Zheng, Xianwei Wang, Xuefu Wang, Jingjing Cong   +12 more
wiley   +1 more source

Cross-sectional seroprevalence study of bovine herpesvirus 1, bovine respiratory syncytial virus, and parainfluenza virus 3 in cattle from Villavicencio, Colombia

BMC Veterinary Research
Background Bovine respiratory disease complex (BRDC) is a widely distributed and multifactorial syndrome, leading to significant economic losses to the cattle industry. Many viruses are considered causative agents of BRDC, including bovine herpesvirus 1 (
Catalina Ballesteros González, Karen Briñez, Julio César Tobón, Danny Wilson Sanjuanelo Corredor, Fernando Vicosa Bauermann, Blanca Lisseth Guzmán Barragán   +5 more
doaj   +1 more source

Application of Bovine Nasal Epithelial Cells as an In Vitro Model for Studying Viral Infection in the Upper Respiratory Tract

Viruses
Bovine respiratory disease complex (BRDC) is a multifactorial and globally prevalent condition involving a combination of viral and bacterial pathogens, as well as environmental stressors.
Malte Pitters, Henrik Fritsch, Ang Su, Klaus Jung, Paul Becher   +4 more
doaj   +1 more source