Results 141 to 150 of about 10,476,926 (247)

Cross-sectional seroprevalence study of bovine herpesvirus 1, bovine respiratory syncytial virus, and parainfluenza virus 3 in cattle from Villavicencio, Colombia

BMC Veterinary Research
Background Bovine respiratory disease complex (BRDC) is a widely distributed and multifactorial syndrome, leading to significant economic losses to the cattle industry. Many viruses are considered causative agents of BRDC, including bovine herpesvirus 1 (
Catalina Ballesteros González, Karen Briñez, Julio César Tobón, Danny Wilson Sanjuanelo Corredor, Fernando Vicosa Bauermann, Blanca Lisseth Guzmán Barragán   +5 more
doaj   +1 more source

Application of Bovine Nasal Epithelial Cells as an In Vitro Model for Studying Viral Infection in the Upper Respiratory Tract

Viruses
Bovine respiratory disease complex (BRDC) is a multifactorial and globally prevalent condition involving a combination of viral and bacterial pathogens, as well as environmental stressors.
Malte Pitters, Henrik Fritsch, Ang Su, Klaus Jung, Paul Becher   +4 more
doaj   +1 more source

Monitoring systems for identifying bovine respiratory disease

, 2015
Accurate diagnosis of bovine respiratory disease (BRD) is a critical component of applying appropriate therapy at the optimal time. Visual observation is the conventional manner for BRD diagnosis; however, this method has been shown to have relatively ...
White, Brad
core   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

A survey of herd-level risk factors for bovine respiratory disease (BRD) in nursing beef calves

, 2012
Surveys by the USDA confirm that bovine respiratory disease (BRD) is the leading cause of death of nursing (preweaned) beef calves three weeks of age and older. Management modifications decrease BRD in some cattle populations; however, management-related
Waggoner, E. R., Matlik, D. K., Jones, A. L., Mason, G. L., Woolums, A. R., Engelken, T. J., Irsik, M., Smith, L. J., Smith, D. R., Berghaus, R. D., White, B. J., Ellis, R. W.   +11 more
core   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Field-validated multiplex RT-qPCR for simultaneous detection of bovine respiratory syncytial virus and bovine parainfluenza virus-3 in bovine respiratory samples

Frontiers in Veterinary Science
Bovine respiratory syncytial virus (BRSV) and bovine parainfluenza virus Type 3 (BPIV3) are ubiquitous respiratory pathogens of cattle, contributing significantly to the bovine respiratory disease (BRD) complex.
Brian Zulauf, Manoj K. Pastey
doaj   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, EarlyView.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source