Results 41 to 50 of about 4,420 (121)

Exploring 6‐Hydroxy‐3‐Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
New therapies are urgently needed for Chagas disease, and screening of 6‐hydroxy‐3‐aryl/heteroarylcoumarin derivatives identified highly selective compounds with potent activity against T. cruzi. In particular, derivative 1f showed submicromolar trypomastigote potency, dual‐stage activity, and inhibition of amastigote‐to‐trypomastigote differentiation,
C. N. Pereira, L. da Silva Lara, S. da Costa Lanera, T. Pérez de Souza, M. C. de Souza Pereira, G. L. Delogu, M. Silva dos Santos, M. J. Matos   +7 more
wiley   +1 more source

Trypanocide usage in the cattle belt of southwestern Uganda

Frontiers in Microbiology, 2023
BackgroundSystematic infrastructure and regulatory weaknesses over many decades, in communities struggling with animal African trypanosomiasis (AAT) would be expected to create an environment that would promote drug misuse and risk development of drug ...
Keneth Iceland Kasozi, Keneth Iceland Kasozi, Ewan Thomas MacLeod, Keith Robert Sones, Keith Robert Sones, Susan Christina Welburn, Susan Christina Welburn   +6 more
doaj   +1 more source

Potential entry pathways for 25 vector‐borne disease agents

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract This Scientific Report identifies the potential entry pathways for 25 selected vector‐borne diseases (VBDs) into currently free EU Member States. The diseases comprise 12 listed under the Animal Health Law (AHL) and 13 non‐listed diseases, selected using predefined eligibility criteria.
European Food Safety Authority (EFSA), Sofie Dhollander, Ieva Baltusyte, Fabio Bigoni, Alessandro Broglia, Jordi Figuerola, Hans‐Hermann Thulke, Miguel Angel Chueca Miranda   +7 more
wiley   +1 more source

Identification and mapping of potential and highly likely vectors for selected vector‐borne diseases in the EU and neighbouring countries

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract This report addresses Term of Reference 1.2 by providing a comprehensive knowledge‐mapping of arthropod vector species competent to transmit selected vector‐borne diseases (VBDs) including VBDs listed under Regulation (EU) 2016/429 and Regulation (EU) 2020/687, as well as additional non‐listed pathogens with potential epidemiological relevance.
European Food Safety Authority (EFSA), Sofie Dhollander, Ieva Baltusyte, Fabio Bigoni, Alessandro Broglia, Jordi Figuerola, Hans‐Hermann Thulke, Miguel Angel Chueca Miranda   +7 more
wiley   +1 more source

Neglected zoonotic diseases in Nigeria: role of the public health veterinarian

The Pan African Medical Journal, 2019
Zoonotic diseases accounts for about 75% of emerging infectious disease and can be devastating to both human and animal health globally. A subset of zoonotic diseases is referred to as "neglected zoonotic diseases - NZDs" as they mainly affect poor ...
Nusirat Elelu, Julius Olaniyi Aiyedun, Ibraheem Ghali Mohammed, Oladapo Oyedeji Oludairo, Ismail Ayoade Odetokun, Kaltume Mamman Mohammed, James Olaniyi Bale, Saka Nuru   +7 more
doaj   +1 more source

Vector‐borne diseases‐knowledge maps

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract This scientific report provides a structured overview of the main characteristics of 25 selected vector‐borne diseases (VBDs) of potential relevance for the EU, including 12 diseases listed under the Animal Health Law (AHL) and 13 non‐listed diseases.
European Food Safety Authority (EFSA), Sofie Dhollander, Ieva Baltusyte, Fabio Bigoni, Alessandro Broglia, Jordi Figuerola, Hans‐Hermann Thulke, Miguel Angel Chueca Miranda   +7 more
wiley   +1 more source

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Alireza Mousavi, Martina Slapničková, Maryam Norouzbahari, Sarah D'Alessandro, Parham Foroumadi, Fariba Peytam, Federica Perego, Eva Doleželová, Zahra Emamgholipour, Maliheh Barazandeh Tehrani, Seyed Esmaeil Sadat‐Ebrahimi, Elahe Hosseinzadeh, Elmira Meghrazi Ahadi, Loghman Firoozpour, Hamidreza Bijanzadeh, Nicoletta Basilico, Alena Zíková, Alireza Foroumadi   +17 more
wiley   +1 more source

A Review of Infectious and Non‐Infectious Causes of Pregnancy Loss in Goats

Reproduction in Domestic Animals, Volume 61, Issue 3, March 2026.
ABSTRACT Goats play a vital role in global agriculture, particularly in developing regions, and are increasingly kept as companion animals. Given their economic and social importance, pregnancy losses in goats represent a substantial challenge, leading to considerable economic losses and raising concerns about animal welfare and public health, as some ...
Friederike Maria Kaus, Hannah Eggimann, Barbara Tschulena, Gaby Hirsbrunner, Patrik Zanolari   +4 more
wiley   +1 more source

Cytotoxicity and Antimicrobial Activity of GaMF1 Analogs

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
GaMF1 is a reported, highly potent inhibitor of mycobacterial ATP synthase. Structural modification of this scaffold significantly changes biological activity. We present GaMF1 analogues with strong antiparasitic effects, potential antiproliferative properties, and discuss the selectivity limitations of the parent compound and its analogues.
Jan Chasák, Petr Vyvlečka, Ivan Nemec, An Matheeussen, Natascha Van Pelt, Paul Cos, Guy Caljon, Vladimír Kryštof, Lucie Brulíková   +8 more
wiley   +1 more source

Weaving knowledges to support wildlife health surveillance in Kenya's pastoral rangelands

Conservation Biology, Volume 40, Issue 1, February 2026.
Abstract In wildlife–livestock–human interfaces, pathogens capable of spreading between wild and domestic animals and humans have important implications for conservation outcomes, economics, and public health. Robust wildlife health surveillance can help address these risks.
Brock Bersaglio, Charis Enns, Nashipai Karinten, Ramson Karmushu, Susanne Shultz   +4 more
wiley   +1 more source