Results 1 to 10 of about 3,124 (266)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Evidence for transient, local ion foreshocks caused by dayside magnetopause reconnection [PDF]

Annales Geophysicae, 2016
We present a scenario resulting in time-dependent behaviour of the bow shock and transient, local ion reflection under unchanging solar wind conditions.
Y. Pfau-Kempf, Y. Pfau-Kempf, H. Hietala, S. E. Milan, L. Juusola, S. Hoilijoki, S. Hoilijoki, U. Ganse, U. Ganse, S. von Alfthan, M. Palmroth   +10 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

Arthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier, Matthew N. Vigliotti, Paige E. Rice, Brian Pietrosimone, Shannon L. Mihalko, Edward H. Ip, Richard F. Loeser, David J. Hunter, Ali Guermazi, Ryan Hill, Santiago Saldana, Kim L. Bennell, Paul DeVita   +12 more
wiley   +1 more source

Observations of a new foreshock region upstream of a foreshock bubble's shock

Geophysical Research Letters, 2016
Earth's foreshock is a region within the solar wind upstream of Earth's bow shock filled with backstreaming solar wind particles reflected at the shock.
Terry Z. Liu, Heli Hietala, Vassilis Angelopoulos, Drew L. Turner   +3 more
doaj   +1 more source

Interplanetary shock transmitted into the Earth's magnetosheath: Cluster and Double Star observations [PDF]

Annales Geophysicae, 2010
On day 7 May 2005, the plasma instruments on board Double Star TC1 and Cluster SC3 spacecraft register inside the magnetosheath, at 19:15:12 and 19:16:20 UT, respectively, a strong pressure pulse due to the impact of an interplanetary shock wave (IS ...
G. Pallocchia, A. A. Samsonov, M. B. Bavassano Cattaneo, M. F. Marcucci, H. Rème, C. M. Carr, J. B. Cao   +6 more
doaj   +1 more source

In Situ Micromechanical Study of Bimodal γ′–γ″ Precipitate Assemblies in Ni–Cr–Al–Nb Superalloy

Advanced Engineering Materials, EarlyView.
A Ni–Cr–Al–Nb superalloy with a bimodal γ′–γ″ precipitate distribution is developed. Composite precipitate assemblies form through heterogeneous nucleation, effectively impeding dislocation motion. Micropillar compression reveals high strength at room and elevated temperatures, governed by precipitate shearing, with coupled faulting mechanisms ...
Ujjval Bansal, Tae‐Hyeok Kang, Pyuck‐Pa Choi, Subin Lee, Christoph Kirchlechner   +4 more
wiley   +1 more source

The Evolution of Aerosol Jet Printing, A Review: Enhancing Material Versatility and Improvements for Next‐Generation Applications

Advanced Materials Technologies, EarlyView.
Aerosol Jet Printing (AJP) has emerged as a versatile additive manufacturing technique for high‐resolution, conformal, and multi‐material printing. This review highlights advances in printable materials, substrate compatibility, post‐processing, characterization, and process innovations, while critically discussing current challenges and future ...
Chandrachur Chatterjee, Rocco Lupoi, Michael J. Gibbons   +2 more
wiley   +1 more source

The Large Magellanic Cloud’s ∼30 kpc Bow Shock and Its Impact on the Circumgalactic Medium

The Astrophysical Journal Letters, 2023
The interaction between the supersonic motion of the Large Magellanic Cloud (LMC) and the circumgalactic medium (CGM) is expected to result in a bow shock that leads the LMC’s gaseous disk.
David J. Setton, Gurtina Besla, Ekta Patel, Cameron Hummels, Yong Zheng, Evan Schneider, Munier Salem   +6 more
doaj   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source