Results 71 to 80 of about 171,393 (337)

ACUTE OBSTRUCTION OF THE BOWELS. [PDF]

JAMA: The Journal of the American Medical Association, 1899
I shall deal with acute obstruction of the bowels from a surgical standpoint, for I am convinced that the few cases which recover without operative interference but emphasize its importance. The results of operations for the relief of the various conditions that produce obstruction are all the while improving.
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Acute small bowel obstruction due to Meckel's diverticulum: An unusual presentation

Journal of Medical and Scientific Research, 2016
Majority of the persons with Meckel’s diverticulum are asymptomatic throughout life. In the symptomatic adults, small bowel obstruction is the most common presentation.
Sandeep P, Papalkar A, Prasad MBV, Varma BM   +3 more
doaj   +1 more source

Gastric perforation and pancreatitis manifesting after an inadvertent nissen fundoplication in a patient with superior mesenteric artery syndrome. [PDF]

, 2009
Superior mesenteric artery (SMA) syndrome is an uncommon but well-recognized clinical entity. It can lead to proximal small bowel obstruction and severe morbidity and mortality in lieu of late diagnosis and concomitant existing comorbidities. We report a
Estrada, JJ, Giuliani, S, Mason, RJ, Petrosyan, M, Rosen, H, Williams, M   +5 more
core   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The microflora of the obstructed bowel

Journal of British Surgery, 1976
Abstract A study of the alterations of intestinal microflora that occur in acute small and large bowel obstruction is presented. The results are discussed in relation to the duration of obstruction, the site of obstruction, the recovery following relief of obstruction and the septic complications which profoundly aflect the prognosis of ...
Philip F. Schofield, Peter A. Sykes, Kenneth H. Boulter   +2 more
openaire   +3 more sources

Early and late complications of bariatric operation. [PDF]

, 2018
Weight loss surgery is one of the fastest growing segments of the surgical discipline. As with all medical procedures, postoperative complications will occur. Acute care surgeons need to be familiar with the common problems and their management. Although
Beekley, Alec, Davis, Kimberly A., Johnson, Dirk C., Lim, Robert   +3 more
core   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Surgical Management of Inguinal Hernias at Bugando Medical Centre in Northwestern Tanzania: Our Experiences in a Resource-Limited Setting. [PDF]

, 2012
Inguinal hernia repair remains the commonest operation performed by general surgeons all over the world. There is paucity of published data on surgical management of inguinal hernias in our environment.
AN Kingsnorth, AR Adesunkanmi, C Schutz, D Maggiore, D Watkin, DC Lewis, DL Crawford, EM Nordberg, ES Garba, EU Hernia Trialists Collaboration, EU Hernia Trialists Collaboration, IG Schools, IL Lichtenstein, IM Rutkow, IVA Nesterenko, JA Álvarez, JD Nathan, Joseph B Mabula, M Baloch, M Ohene-Yeboah, M Ohene-Yeboah, ME McFarlane, MR Gulzar, N Ali, N Mbah, NS Williams, OA Awoyobi, OD Osifo, P Lal, P Primatesta, P Sanjay, Phillipo L Chalya, S Post, S Rai, SD Berliner, SR Menakuru, T Fasih, U Wolters, VM Kimyil   +38 more
core   +2 more sources

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source