Results 81 to 90 of about 13,146 (187)

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, Volume 2, Issue 4, August 2026.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

Dynamic, Unconstrained Optimization of Secreted Enzyme Production in Fed‐Batch Fermentation Using Reinforcement Learning

Biotechnology and Bioengineering, Volume 123, Issue 8, Page 2024-2036, August 2026.
ABSTRACT Reinforcement learning (RL) has been used to control a wide range of dynamic processes, especially ones that are too complex to model well or have stochastic environmental perturbations. Fed‐batch fermentations are subject to changes in starting cell growth rates and process variations that can affect cell growth and secreted target production.
Sai Harish Uthravalli, Sakib Ferdous, J. Michael Hess, Nigel F. Reuel   +3 more
wiley   +1 more source

A Box-Behnken experimental design for microwave assisted extraction optimization of pectin from citron peel [PDF]

Journal of Food and Bioprocess Engineering, 2018
Microwave assisted extraction technique was employed to extract pectin from citron peel. Box-Behnken design was applied to investigate the influence of irradiation time, microwave power and pH on the yield and DE of pectin. The finding indicated that the
Bahare Pasandide, Faramarz khodaiyan, Zeinab Mousavi, Seyed Saeid Hosseini   +3 more
doaj  

From Fish Waste to Stable Omega‐3 Bioactive Lipids: Encapsulation Strategies and a Conceptual Framework for Antioxidant and Antimicrobial Functional Food Fortification

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Fish waste is valorized into omega‐3‐rich bioactive lipids (EPA and DHA), followed by stabilization through advanced encapsulation technologies to prevent oxidation and improve storage stability. Encapsulation protects polyunsaturated fatty acids from oxidation, improves storage stability, enables controlled gastrointestinal release, and enhances ...
Abebe Desalegn, Habtamu Admassu, Gadissa Mosisa, Gebeyehu Ayele, Molla Abeje, Tanaji Kudre   +5 more
wiley   +1 more source

Ultrasonic nanoemulsification of Aloe vera: formulation, optimization, and characterization

Journal of Excipients and Food Chemicals, 2022
Aloe vera is a widely used plant in the pharmaceutical and cosmetic industry due to its anti-inflammatory, healing, moisturizing, antioxidant, anti-aging, and depigmentation properties, several of which have been attributed to the Aloesin, a compound ...
Andrea Catalina Hernández Muñoz, Sandra Milena Echeverry, Diana Marcela Aragón Novoa   +2 more
doaj  

Development of Functional Bread Fortified with Hawthorn Leaf Phenolic Extract: Evaluation of Technological Performance and Phenolic Bioaccessibility

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
This study investigates the production of hawthorn (Crataegus azarolus) leaf extract–fortified functional bread. Ultrasound‐assisted extraction was optimized using Response Surface Methodology (Box–Behnken design) by adjusting extraction time, temperature, and ethanol concentration.
Semra Topuz Türker, Esra Esin, Mustafa Bayram, Cemal Kaya   +3 more
wiley   +1 more source

Chemometrically assisted optimization and validation of the HPLC method for the analysis of alectinib and its related impurity with measurement uncertainty evaluation and whiteness, blueness, and greenness profile assessments

BMC Chemistry
Alectinib, the most common second-generation anaplastic lymphoma kinase inhibitor, is efficacious against various anaplastic lymphoma kinase mutations and is utilized in the treatment of non-small cell lung cancer. In this work, the determination of both
Serkan Levent, Abeer Elriş, Hazal Avcı, Saniye Özcan, Nafiz Öncü Can   +4 more
doaj   +1 more source

LOGICAL AND EXPERIMENTAL DESIGN FOR PHENOL DEGRADATION USING IMMOBILIZED ACINETOBACTER SP. CULTURE

International Islamic University Malaysia Engineering Journal, 2010
Phenol degradation processes were conducted through a series of enzymatic reactions effects and is affect by different components of the microbial metabolic flux.
Amro Abd Al Fattah Amara, Soheir R. Salem   +1 more
doaj   +1 more source

Comparative Phytochemical Profiles and Antioxidant Potential of Green and Variegated Morphotypes of Alternanthera bettzickiana Under Optimized Extraction Conditions

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Green and variegated Alternanthera bettzickiana morphotypes were compared after optimizing extraction (Box–Behnken design–RSM: 90% ethanol, 50°C, 2 h, 10 mg/mL). The green morphotype had higher phenolic content, FRAP, and ORAC activity, while the variegated morphotype had higher flavonoid and anthocyanin content.
Sirinapa Thangsiri, Woorawee Inthachat, Piya Temviriyanukul, Amornrat Aursalung, Yuraporn Sahasakul, Uthaiwan Suttisansanee   +5 more
wiley   +1 more source

Optimizing the Maximum Recovery of Dihydromyricetin from Chinese Vine Tea, Ampelopsis grossedentata, Using Response Surface Methodology

Molecules, 2017
This work provides an optimized extraction approach intended to maximize the recovery of dihydromyricetin (DHM) from Chinese vine tea (Ampelopsis grossedentata) leaves.
Umair Muhammad, Hedong Lu, Juan Wang, Jinzhi Han, Xiaoyu Zhu, Zhaoxin Lu, Sultana Tayyaba, Yousef I. Hassan   +7 more
doaj   +1 more source