Results 91 to 100 of about 964,966 (303)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

A Boy and a Box: Resting [PDF]

open access: yes, 2020
Resting Stoneware with Glaze 6.5” x 5.5” x 3” 2020 In this final piece of this series, after a long journey of creating, Redd rests. He does so by using the box in its simplest form.
Carper, Jacalyn
core  

Microstructure quantitative analysis of multi-scale pores in C/SiC composites via micro-CT for revealing correlations with interlaminar shear properties

open access: yesJournal of Materials Research and Technology
Fiber reinforced Ceramic Matrix composites (CMCs) are widely used in aerospace fields due to their excellent properties. However, pores are inevitable during CMCs manufacturing, due to their anisotropy and fabrication complexity.
Wenhan Qu   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

A Boy and a Box: Collecting [PDF]

open access: yes, 2020
Collecting Stoneware with Glaze 6.5” x 6.5” 6.5” 2020 Redd decides to create with the box, so he begins to collect other materials to help him in his creative journey. We see him struggling to pull a wagon full of his materials.
Carper, Jacalyn
core  

Multifractal portrayal of the Swiss population

open access: yesCybergeo, 2015
Fractal geometry is a fundamental approach for describing the complex irregularities of the spatial structure of point patterns. The present research characterizes the spatial structure of the Swiss population distribution in the three Swiss geographical
Carmen Delia Vega Orozco   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Génération de semis de points fractals : une méthode du comptage de boites inversée

open access: yesCybergeo, 2015
Fractal dimension is useful to characterize the structure of spatial objects such as urban structures or river networks. However, fractal analysis is underutilized for point processes.
Cyril Fleurant
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Box-Counting Dimension Using Triangles

open access: yes, 2016
An alternate definition of the box-counting dimension is proposed, to provide a better approximation for fractals involving rotation such as the 'Bradley Spiral' structure. A curve fitting comparison of this definition with the box-counting dimension is also presented.
Athar, Tazeen   +2 more
openaire   +2 more sources

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