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Formulation and optimization of rifampicin microparticles by Box-Behnken statistical design
Pharmaceutical Development and Technology, 2011The objective of the present study was to optimize and evaluate in vitro gastroretentive performance of rifampicin microparticles. Formulations were optimized using design of experiments by employing a 4-factor, 3-level Box-Behnken statistical design. Independent variables studied were the ratio of polymers (Eudragit RSPO: ethyl cellulose), inert drug ...
D P, Maurya +3 more
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Reinvestigating nanoprecipitation via Box–Behnken design: a systematic approach
Journal of Microencapsulation, 2014This work demonstrates Box-Behnken design (BBD)'s capability in exploring scientific principles governing a process, different from its use in process optimisation. We have investigated nanoprecipitation (NP) of temozolomide with polycaprolactone. Five factors, surfactant, stirring speed (SS), dropping rate (DR), phase-volume ratio (PVR) and drug ...
Yuvraj, Singh +3 more
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Determination of Alendronate Sodium by Box-Behnken Statistical Design
Chromatographia, 2010Spectrophotometric and LC methods have been developed and validated for the analysis of alendronate sodium in tablet dosage forms. Methods were based on reaction of the primary amino group of alendronate with ninhydrin reagent in methanolic solution of sodium bicarbonate.
Shaheen Sultana +4 more
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Box–Behnken Designs and Their Applications in Pharmaceutical Product Development
2021Box–Behnken designs (BBDs) are the very efficient response surface design which provides information exclusively on the effect of experiment variables and overall experimental error in a minimum number of required runs. These designs possess very good symmetry and rotatability and also produce minimal experimental runs, as compared to the popular CCD ...
Sarwar Beg, Sohail Akhter
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Optimisation for Photocatalytic Degradation of Malathion by Box–Behnken Design
Materials Today: Proceedings, 2018Abstract Malathion is a pesticide that is generally utilized as a part of agriculture, private finishing, open amusement regions, and in general wellbeing nuisance control projects, for example, mosquito annihilation. In the US, it is the most ordinarily utilized organophosphate insecticide.
P.Neelima Reddi +3 more
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Some new augmented fractional Box–Behnken designs
Communications in Statistics - Theory and Methods, 2016ABSTRACTThe augmented Box–Behnken designs are used in the situations in which Box–Behnken designs (BBDs) could not estimate the response surface model due to the presence of third-order terms in the response surface models. These designs are too large for experimental use.
Fareeha Rashid +3 more
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A note on the robustness of Box-Behnken designs to the unavailability of data
Metrika, 1998zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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OPTIMISATION OF REACTIVE DYE DEGRADATION BY LACCASE USING BOX–BEHNKEN DESIGN
Environmental Technology, 2008A three-level Box-Behnken factorial design with three factors and the Response Surface Methodology were used to optimise the colour removal of the reactive textile dye, Colour Index (C.I.) reactive red 180, by commercial laccase. A mathematical model was developed to study the effect of temperature, pH, enzyme concentration and their interactions on ...
R O, Cristóvão +4 more
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Application of response surface methodology with a Box–Behnken design for struvite precipitation
Advanced Powder Technology, 2019Abstract Struvite crystals were precipitated by the reaction of magnesium chloride hexahydrate and ammonium dihydrogen phosphate using different concentrations of citric acid as the additive (100, 300, and 500 ppm). The structure, morphology, functional groups and particle size of the crystals were evaluated experimentally by scanning electron ...
Sevgi Polat, Perviz Sayan
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