Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Cardiorespiratory adaptations to high-intensity interval training in young boxers: A randomized controlled study. [PDF]
Medicine (Baltimore)Cinarli S +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
An octopamine-glutamate cotransmitting neuron gates aggressive escalation through layered inhibition in <i>Drosophila</i>. [PDF]
Sci AdvPrunier A +7 more
europepmc +1 more source
[Portrait of Ern Waddy, heavyweight boxing champion of Australia, 1923] [picture] /
, 1923 "Frank A. McNeill, Baby King, Gawler Place, Adelaide"--Label on mount.; Condition: Glued to mount; foxing.; Part of: Arnold Thomas boxing collection.; Title devised by cataloguer based on acquisition documentation.; Also available in an electronic ...
McNeill, Frank A. (Photographer)
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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Effects of In-Season Velocity-Based Resistance Training on Boxing-Specific Performance in Collegiate Boxers: A Companion Report from a Randomized Controlled Trial. [PDF]
J Funct Morphol KinesiolHan Y, Xie Y, Zhang Z, García-Ramos A.
europepmc +1 more source
Portrait of Abe Hicken in boxing pose [picture].
, 1879 Title devised by cataloguer based on inscription.; Inscription: "Abe Hicken who lost title to Larry Foley Mch 20, 1879"--Typed, on piece of paper glued to mount, below photo.; Part of: Arnold Thomas boxing collection.; Also available in an electronic ...
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Bio-Inspired Enhanced Adaptive Centered Collision Optimizer for Hyperparameter Optimization of Multi-Scale Spatio-Temporal ConvNeXt in Boxing Action Recognition. [PDF]
Biomimetics (Basel)Liu T.
europepmc +1 more source