The key enzyme PYCR1 in proline metabolism: a dual driver of cancer progression and fibrotic remodeling. [PDF]
Guo P +13 more
europepmc +1 more source
RNLS promotes ovarian cancer growth and inhibits ferroptosis via mediating STAT3. [PDF]
Lin L +7 more
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Hit-to-Lead Studies of Pyrazinylpiperazines against Visceral Leishmaniasis: Pharmacokinetic Profile and <i>In Vivo</i> Efficacy of Potent Compounds against <i>Leishmania infantum</i>. [PDF]
Jacques Dit Lapierre TJW +17 more
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Understanding physiological adaptations of pregnancy to the chronic hypoxia of high altitude to inform obstetrical and neonatal care. [PDF]
Arenas GA +6 more
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Human TRPV1 is an efficient thermogenetic actuator for chronic neuromodulation. [PDF]
Maltsev DI +16 more
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Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase [PDF]
mTOR immunoprecipitates contain two 4E-BP1 protein kinase activities. One appears to be due to mTOR itself and results in the phosphorylation of 4E-BP1 on residues T36 and T45, as shown previously by others.
Denton, Richard M +5 more
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International audienceThe suppressor of translation initiation 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival.
S Pyronnet, C Susini
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