Results 151 to 160 of about 49,831 (180)

A nanoencapsulated oral formulation of fenretinide promotes local and metastatic breast cancer dormancy in HER2/neu transgenic mice. [PDF]

J Exp Clin Cancer Res
De Angelis ML, Francescangeli F, Aricò E, Verachi P, Zucchetti M, Matteo C, Petricci E, Pilozzi E, Orienti I, Boe A, Eramo A, Rossi R, Corati T, Macchia D, Pacca AM, Zeuner A, Baiocchi M.   +16 more
europepmc   +1 more source

<i>NPRL2</i> gene therapy induces effective antitumor immunity in <i>KRAS/STK11</i> mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model. [PDF]

Elife
Meraz IM, Majidi M, Song R, Meng F, Gao L, Wang Q, Wang J, Shpall EJ, Roth JA.   +8 more
europepmc   +1 more source

Integrated metabolomics and transcriptomics reveal the potential of hydroxy-alpha-sanshool in alleviating insulin resistance. [PDF]

Mol Med
Zhu Y, Yang P, Ren T, Chen Z, Tian H, Wang M, Zhang C.   +6 more
europepmc   +1 more source

A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments. [PDF]

Nat Cell Biol
Chidley C, Darnell AM, Gaudio BL, Lien EC, Barbeau AM, Vander Heiden MG, Sorger PK.   +6 more
europepmc   +1 more source

Mitolnc controls cardiac BCAA metabolism and heart hypertrophy by allosteric activation of BCKDH. [PDF]

Nucleic Acids Res
Weiss M, Hettrich S, Hofmann T, Hachim S, Günther S, Braun T, Boettger T.   +6 more
europepmc   +1 more source

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Eukaryotic Initiation Factor 4E (eIF4E) sequestration mediates 4E-BP1 response to rapamycin

International Journal of Biological Macromolecules, 2019
The cap dependent translation initiation is a tightly controlled process of cooperative ternary complex formation by 4E-BP1, eIF4E and the 5' cap of eukaryotic mRNA in response to environmental cues like glucose, nutrients and growth factor levels. Based
Asiya Batool, Sheikh Tahir Majeed, Sabreena Aashaq   +2 more
exaly   +2 more sources

Effects of bioaugmentation by isolated Achromobacter xylosoxidans BP1 on PAHs degradation and microbial community in contaminated soil.

Journal of Environmental Management, 2023
Polycyclic aromatic hydrocarbons (PAHs) are a group of organic pollutants ubiquitous and persistent in soil. In order to provide a viable solution for bioremediation of PAHs-contaminated soil, a strain of Achromobacter xylosoxidans BP1 with superior PAHs
Ben Zhang, Wei Xu, Yichi Ma, Xiaolong Gao, Huyang Ming, Jianli Jia   +5 more
semanticscholar   +1 more source

The mTOR/4E-BP1/eIF4E signalling pathway as source of cancer drug targets.

Current Medicinal Chemistry, 2022
The mechanistic/mammalian target of rapamycin (mTOR) is the crucial hub of signalling pathways that regulate essential steps in the cell life cycle. Once incorporated in the mTORC1 complex, mTOR phosphorylates the eukaryotic initiation factor 4E (eIF4E)-
C. Maracci, S. Motta, A. Romagnoli, Matteo Costantino, P. Perego, D. Di Marino   +5 more
semanticscholar   +1 more source

PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury.

Journal of Hazardous Materials, 2021
To identify key signaling pathways involved in ambient particulate matter (PM)-induced pulmonary injury, we generated a mouse model with myeloid-specific deletion of Ppp2r1a gene (encoding protein phosphatase 2 A (PP2A) A subunit), and conducted ...
Shen Chen, Li-ping Chen, Lizhu Ye, Yue-ming Jiang, Qiong Li, Haiyan Zhang, Rui Zhang, Huiyao Li, Dianke Yu, Rong Zhang, Yu-jie Niu, Qun Zhao, Jianhui Liu, Gangfeng Ouyang, M. Aschner, Yu-xin Zheng, Lihua Zhang, Wen Chen, Daochuan Li   +18 more
semanticscholar   +1 more source

Overexpression of BP1, an isoform of Homeobox Gene DLX4, promotes cell proliferation, migration and predicts poor prognosis in endometrial cancer.

Gene, 2019
The expression of homeobox gene DLX4 has been verified in some tumors, but not in endometrial cancer. We found that expression of DLX7, a splicing isoform of DLX4, did not show any significant difference in expression between endometrial cancer and ...
Lin Zhang, Y. Wan, Yi Jiang, Zihan Zhang, Shan Shu, Wenjun Cheng, J. Lang   +6 more
semanticscholar   +1 more source