Results 51 to 60 of about 36,655 (113)

Upregulation of the Nitrosylome in Bipolar Disorder Type 1 (BP1), but not BP2, and Major Depression: Increased IgM Antibodies to Nitrosylated Conjugates are Associated with Indicants of Leaky Gut

, 2019
Objective: Major depression (MDD) and a lifetime history of MDD are characterized by increased nitrosylation, while bipolar disorder type 1 (BP1), but not BP2, is accompanied by highly increased levels of oxidative stress and nitric oxide (NO) production.
M. Maes, D. Simeonova, D. Stoyanov, J. Leunis   +3 more
semanticscholar   +1 more source

Luteolin, a natural flavonoid, inhibits methylglyoxal induced apoptosis via the mTOR/4E-BP1 signaling pathway

Scientific Reports, 2017
Methylglyoxal (MG) accumulation has been observed in human cerebrospinal fluid and body tissues under hyperglycaemic conditions. Recent research has demonstrated that MG-induces neuronal cell apoptosis, which promotes the development of diabetic ...
Yi Liu, Jie Huang, Xian Zheng, Xia Yang, Yan Ding, Tongyong Fang, Yu-yun Zhang, Shuai-shuai Wang, Xiaofei Zhang, Xuan Luo, Anlei Guo, K. Newell, Yinghua Yu, Xu-Feng Huang   +13 more
semanticscholar   +1 more source

The consequences of increased 4E-BP1 in polycystic kidney disease.

Human Molecular Genetics, 2019
Autosomal Dominant Polycystic kidney disease (ADPKD) is the most common hereditary renal disease, characterized by cyst formation and growth. Hyperproliferation is a major contributor to cyst growth.
S. Holditch, C. N. Brown, Daniel J. Atwood, Deepak Pokhrel, Sara E. Brown, A. M. Lombardi, Khoa N. Nguyen, Ryan C. Hill, M. Lanaspa, Katharina Hopp, M. Weiser-Evans, C. Edelstein   +11 more
semanticscholar   +1 more source

Regulation of 4E-BP1 activity in the mammalian oocyte

Cell Cycle, 2017
Fully grown mammalian oocytes utilize transcripts synthetized and stored during earlier development. RNA localization followed by a local translation is a mechanism responsible for the regulation of spatial and temporal gene expression. Here we show that
Denisa Jansová, Marketa Koncicka, Anna Tetkova, R. Cerna, R. Malik, Edgar Del Llano, M. Kubelka, A. Šušor   +7 more
semanticscholar   +1 more source

Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1

Nature Communications, 2017
Loss of 4E-BP1 expression has been linked to cancer progression and resistance to mTOR inhibitors, but the mechanism underlying 4E-BP1 downregulation in tumors remains unclear. Here we identify Snail as a strong transcriptional repressor of 4E-BP1.
Jun Wang, Q. Ye, Yanan Cao, Yubin Guo, Yubin Guo, Xiuping Huang, Xiuping Huang, Wenting Mi, Wenting Mi, Side Liu, Chi Wang, Hsin-Sheng Yang, Binhua P. Zhou, B. Evers, Q. She   +14 more
semanticscholar   +1 more source

Geno- and phenotypic characteristics and clinical outcomes of CACNA1C gene mutation associated Timothy syndrome, "cardiac only" Timothy syndrome and isolated long QT syndrome 8: A systematic review. [PDF]

Front Cardiovasc Med, 2022
Borbás J, Vámos M, Hategan L, Hanák L, Farkas N, Szakács Z, Csupor D, Tél B, Kupó P, Csányi B, Nagy V, Komócsi A, Habon T, Hegyi P, Sepp R.   +14 more
europepmc   +1 more source

Poster Sessions

HemaSphere, Volume 9, Issue S1, June 2025.
wiley   +1 more source

Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy.

Brain : a journal of neurology, 2021
Lena H. Nguyen, Youfen Xu, Travorn Mahadeo, Longbo Zhang, Tiffany V. Lin, Heather A. Born, Anne E. Anderson, A. Bordey   +7 more
semanticscholar   +1 more source

UEG Week 2024 Moderated Posters

United European Gastroenterology Journal, Volume 12, Issue S8, Page 201-664, October 2024.
wiley   +1 more source

A review of the cognitive impact of neurodevelopmental and neuropsychiatric associated copy number variants. [PDF]

Transl Psychiatry, 2023
Molloy CJ, Quigley C, McNicholas Á, Lisanti L, Gallagher L.   +4 more
europepmc   +1 more source