Results 51 to 60 of about 43,290 (163)

eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.

JCI Insight, 2019
Pancreatic ductal adenocarcinoma (PDAC) relies on hyperactivated protein synthesis. Consistently, human and mouse PDAC lose expression of the translational repressor and mTOR target 4E-BP1.
D. Müller, Sauyeun Shin, T. Goullet de Rugy, R. Samain, R. Baer, Manon Strehaiano, Laia Masvidal-Sanz, J. Guillermet-Guibert, C. Jean, Yoshinori Tsukumo, N. Sonenberg, Frédéric Marion, N. Guilbaud, J. Hoffmann, O. Larsson, C. Bousquet, S. Pyronnet, Y. Martineau   +17 more
semanticscholar   +1 more source

Polymetamorphism during the Grenvillian Orogeny in SE Ontario: Results from trace element mapping, in situ geochronology, and diffusion geospeedometry

Journal of Metamorphic Geology, Volume 42, Issue 1, Page 35-61, January 2024.
Abstract The Flinton Group is a metasedimentary succession of the Grenville Province in SE Ontario, potentially allowing insight into the tectono‐thermal evolution of continental crust during the Mesoproterozoic. At its Green Bay locality, Flinton Group metapelites of the staurolite zone contain abundant, post‐kinematic garnet porphyroblasts.
F. Gaidies, T. Mccarron, A. D. Simpson, R. M. Easton, S. Glorie, B. Putlitz, K. Trebus   +6 more
wiley   +1 more source

O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1–dependent mitochondrial dysfunction in the retina

Journal of Biological Chemistry, 2019
Diabetes promotes the posttranslational modification of proteins by O-linked addition of GlcNAc (O-GlcNAcylation) to Ser/Thr residues of proteins and thereby contributes to diabetic complications.
Sadie K. Dierschke, William P. Miller, John S. Favate, Premal Shah, Y. Imamura Kawasawa, Anna C. Salzberg, S. Kimball, L. Jefferson, Michael D. Dennis   +8 more
semanticscholar   +1 more source

ABORTUS DALAM PANDANGAN HUKUM ISLAM

Hunafa: Jurnal Studia Islamika, 2013
Generally, abortion done in case of unwanted pregnancy and was usually motivated by a variety of factors, including economic, social, contraceptive failure in married couples, as well as sex of unmarriad couples.
Zulfahmi Alwi
doaj  

Translational repression of Ccl5 and Cxcl10 by 4E‐BP1 and 4E‐BP2 restrains the ability of mouse macrophages to induce migration of activated T cells

European Journal of Immunology, 2019
Signaling through the mechanistic target of rapamycin complex 1 (mTORC1) is a major regulatory node of pro‐inflammatory mediator production by macrophages (MΦs).
M. William, L. Leroux, Visnu Chaparro, T. Graber, T. Alain, M. Jaramillo   +5 more
semanticscholar   +1 more source

جوامع الکلم، آنحضور صلی علیہ و سلم کا نادر نمونہ کلام

The Islamic Culture, 2018
جوامع الکلم، آنحضور صلی علیہ و سلم کا نادر نمونہ ...
Muhammad Iqbal
doaj  

Mitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E)

Journal of Biological Chemistry, 2019
Eukaryotic translation initiation factor 4E (eIF4E)–binding protein 1 (4E-BP1) inhibits cap-dependent translation in eukaryotes by competing with eIF4G for an interaction with eIF4E.
Rui Sun, Erdong Cheng, C. Velásquez, Yuan Chang, P. Moore   +4 more
semanticscholar   +1 more source

قیس المنقری ؓ عنہ و حدیثہ

The Islamic Culture, 2018
قیس المنقری ؓ عنہ و ...
Abdul Aziz Al Fareeh
doaj  

4E‐BP1 and 4E‐BP2 double knockout mice are protected from aging‐associated sarcopenia

Journal of Cachexia, Sarcopenia and Muscle, 2019
Sarcopenia is the loss of muscle mass/function that occurs during the aging process. The links between mechanistic target of rapamycin (mTOR) activity and muscle development are largely documented, but the role of its downstream targets in the ...
O. Le Bacquer, Kristell Combe, V. Patrac, B. Ingram, L. Combaret, D. Dardevet, C. Montaurier, J. Salles, C. Giraudet, C. Guillet, N. Sonenberg, Y. Boirie, S. Walrand   +12 more
semanticscholar   +1 more source

فکر الواقع و فقہ الواقع فی شرط الذکورۃ لتولی المراۃ القضاء فی الفقہ الاسلامی (القسم الثانی)

The Islamic Culture, 2018
فکر الواقع و فقہ الواقع فی شرط الذکورۃ لتولی المراۃ القضاء فی الفقہ الاسلامی (القسم الثانی)
Yahya Ramz Kokish
doaj