Results 81 to 90 of about 49,831 (180)

O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1–dependent mitochondrial dysfunction in the retina

Journal of Biological Chemistry, 2019
Diabetes promotes the posttranslational modification of proteins by O-linked addition of GlcNAc (O-GlcNAcylation) to Ser/Thr residues of proteins and thereby contributes to diabetic complications.
Sadie K. Dierschke, William P. Miller, John S. Favate, Premal Shah, Y. Imamura Kawasawa, Anna C. Salzberg, S. Kimball, L. Jefferson, Michael D. Dennis   +8 more
semanticscholar   +1 more source

Parent-of-Origin Effects in 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome

International Journal of Molecular Sciences, 2019
To identify whether parent-of-origin effects (POE) of the 15q11.2 BP1-BP2 microdeletion are associated with differences in clinical features in individuals inheriting the deletion, we collected 71 individuals reported with phenotypic data and known ...
K. W. Davis, Moises A. Serrano, S. Loddo, Catherine Robinson, V. Alesi, B. Dallapiccola, A. Novelli, M. Butler   +7 more
semanticscholar   +1 more source

Caffeine Potentiates Ethanol-Induced Neurotoxicity Through mTOR/p70S6K/4E-BP1 Inhibition in SH-SY5Y Cells

International journal of toxicology, 2020
Caffeine is a popular psychostimulant, which is frequently consumed with ethanol. However, the effects of caffeine on neuronal cells constantly exposed to ethanol have not been investigated.
Pongsak Sangaunchom, P. Dharmasaroja
semanticscholar   +1 more source

4E‐BP1 and 4E‐BP2 double knockout mice are protected from aging‐associated sarcopenia

Journal of Cachexia, Sarcopenia and Muscle, 2019
Sarcopenia is the loss of muscle mass/function that occurs during the aging process. The links between mechanistic target of rapamycin (mTOR) activity and muscle development are largely documented, but the role of its downstream targets in the ...
O. Le Bacquer, Kristell Combe, V. Patrac, B. Ingram, L. Combaret, D. Dardevet, C. Montaurier, J. Salles, C. Giraudet, C. Guillet, N. Sonenberg, Y. Boirie, S. Walrand   +12 more
semanticscholar   +1 more source

Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

Periodontology 2000, Volume 94, Issue 1, Page 257-414, February 2024.
Abstract Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases ...
Richard J. Miron, Nathan E. Estrin, Anton Sculean, Yufeng Zhang   +3 more
wiley   +1 more source

Hz. Âişe’nin Hayatı, Şahsiyeti ve İslâm Tarihindeki Yeri

Cumhuriyet İlahiyat Dergisi, 2017
İslâm’ın ilk muhatapları olan sahâbe üzerine yapılacak çalışmalar, İslâm’ı doğru anlamak için önem arz etmektedir. Bazı sahâbîler bazı özellikleriyle temayüz etmiş, İslâm tarihi ve medeniyetinde özel bir ilgiye mazhar olmuşlardır. Bu araştırmanın konusu,
Ömer Sabuncu
doaj  

Mitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E)

Journal of Biological Chemistry, 2019
Eukaryotic translation initiation factor 4E (eIF4E)–binding protein 1 (4E-BP1) inhibits cap-dependent translation in eukaryotes by competing with eIF4G for an interaction with eIF4E.
Rui Sun, Erdong Cheng, C. Velásquez, Yuan Chang, P. Moore   +4 more
semanticscholar   +1 more source

Translational repression of Ccl5 and Cxcl10 by 4E‐BP1 and 4E‐BP2 restrains the ability of mouse macrophages to induce migration of activated T cells

European Journal of Immunology, 2019
Signaling through the mechanistic target of rapamycin complex 1 (mTORC1) is a major regulatory node of pro‐inflammatory mediator production by macrophages (MΦs).
M. William, L. Leroux, Visnu Chaparro, T. Graber, T. Alain, M. Jaramillo   +5 more
semanticscholar   +1 more source

Polymetamorphism during the Grenvillian Orogeny in SE Ontario: Results from trace element mapping, in situ geochronology, and diffusion geospeedometry

Journal of Metamorphic Geology, Volume 42, Issue 1, Page 35-61, January 2024.
Abstract The Flinton Group is a metasedimentary succession of the Grenville Province in SE Ontario, potentially allowing insight into the tectono‐thermal evolution of continental crust during the Mesoproterozoic. At its Green Bay locality, Flinton Group metapelites of the staurolite zone contain abundant, post‐kinematic garnet porphyroblasts.
F. Gaidies, T. Mccarron, A. D. Simpson, R. M. Easton, S. Glorie, B. Putlitz, K. Trebus   +6 more
wiley   +1 more source

PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target

Virulence, 2017
Rotavirus infection is a major cause of severe dehydrating diarrhea in infants younger than 5 y old and in particular cases of immunocompromised patients irrespective to the age of the patients. Although vaccines have been developed, antiviral therapy is
Yuebang Yin, W. Dang, Xinying Zhou, Lei Xu, Wenshi Wang, W. Cao, Sunrui Chen, Junhong Su, Xuepeng Cai, Shaobo Xiao, M. Peppelenbosch, Q. Pan   +11 more
semanticscholar   +1 more source