Results 161 to 170 of about 122,466 (202)

Perforating corneal injury in rat and pentadecapeptide BPC 157

Experimental Eye Research, 2015
Based on its healing effects in various tissues, we hypothesized that the stable gastric pentadecapeptide BPC 157 heals corneal ulcerations in rats and effects corneal transparency. We made a penetrant linear 2-mm incision in the paralimbal region of the left cornea at the 5 o'clock position with a 20-gauge MVR incision knife at 45° under an operating ...
Sanja, Masnec, Antonio, Kokot, Mirna, Zlatar, Miro, Kalauz, Kristian, Kunjko, Bozo, Radic, Robert, Klicek, Domagoj, Drmic, Ratimir, Lazic, Luka, Brcic, Radivoje, Radic, Renata, Ivekovic, Sven, Seiwerth, Predrag, Sikiric   +13 more
openaire   +4 more sources

BPC 157's effect on healing

Journal of Physiology-Paris, 1997
The 15 amino acid agent BPC 157, showing a wide range of organoprotective action in different experimental models, was used in our experiments in order to establish its influence on different elements connected with the healing process. Elements thought to be of greatest importance in the process of healing are formation of granulation tissue ...
Seiwerth, Sven, Sikirić, Predrag, Grabarević, Željko, Zoričić, Ivan, Hanževački, Miro, Ljubanović, Danica, Ćorić, Vedran, Konjevoda, Paško, Petek, Marijan, Ručman, Rudolf, Turković, Branko, Perović, Darko, Mikuš, Darko, Jandrijević, Stipe, Medvidović, M., Tadić, Tamara, Romac, Branka, Kos, Josip, Perić, Josip, Kolega, Marko   +19 more
openaire   +4 more sources

BPC 157 and Blood Vessels

Current Pharmaceutical Design, 2014
This review focuses on the described effects of BPC 157 on blood vessels after different types of damage, and elucidate by investigating different aspects of vascular response to injury (endothelium damage, clotting, thrombosis, vasoconstriction, vasodilatation, vasculoneogenesis and edema formation) especially in connection to the healing processes ...
Seiwerth, Sven, Brčić, Luka, Batelja Vuletić, Lovorka, Kolenc, Danijela, Aralica, Gorana, Mišić, Marija, Zenko, Anita, Drmić, Domagoj, Rucman, Rudolf, Sikirić, Pradrag   +9 more
openaire   +2 more sources

Pentadecapeptide BPC 157 efficiently reduces radiation-induced liver injury and lipid accumulation through Kruppel-like factor 4 upregulation both in vivo and in vitro.

Life Science, 2022
AIMS Radiation-induced liver disease (RILD) is the major complication for cancer patients after radiation therapy. We investigated the protective effects of BPC 157 peptide in reducing RILD. MATERIALS AND METHODS Mice were irradiated with a single dose
Bing-Shen Huang, Shih-Chiang Huang, Fan-Hsin Chen, Y. Chang, Hsiu-Fu Mei, Hsiu-Yun Huang, Wan-Yu Chen, J.-H. Su Pang   +7 more
semanticscholar   +1 more source

Stable Gastric Pentadecapeptide BPC 157-NO-system Relation

Current Pharmaceutical Design, 2014
We reviewed stable gastric pentadecapeptide BPC 157-NO-system-relation, its close participation in Moncada's (maintained vascular integrity, platelets control) homeostatic healing response of NO-system to injury. Namely, BPC 157's particular healing effect also affects all events after vascular integrity loss (dependent on circumstances, it reduces ...
Sikirić, Predrag, Seiwerth, Sven, Ručman, Rudolf, Turković, Branko, Stančić - Rokotov, Dinko, Brčić, Luka, Sever, Marko, Kliček, Robert, Radić, Božo, Drmić, Domagoj, Ilić, Spomenko, Kolenc, Danijela, Aralica, Gorana, Stupnišek, Marijana, Šuran, Jelena, Barišić, Ivan, Džidić, Senka, Vrčić, Hrvoje, Šebečić, Božidar   +18 more
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Stable Gastric Pentadecapeptide BPC 157 and NO-System

2023
Stable gastric pentadecapeptide BPC 157 is known with very safe profile when used to be in ulcerative colitis and now multiple sclerosis trial, lethal dose (LD1) not achieved. Its pleiotropic beneficial effects were largely combined with its particular modulatory effect on NO-system functions, providing that BPC 157 may counteract adverse effect of ...
Predrag Sikiric, Domagoj Drmic, Alenka Boban Blagaic, Ante Tvrdeic, Ivan Krezic, Slaven Gojkovic, Helena Zizek, Suncana Sikiric, Sanja Strbe, Ivan Marija Smoday, Eva Lovric, Anita Skrtic, Sven Seiwerth   +12 more
openaire   +2 more sources

Stable gastric pentadecapeptide BPC 157 heals rat colovesical fistula

European Journal of Pharmacology, 2016
To establish the effects of BPC 157 on the healing of rat colovesical fistulas, Wistar Albino male rats were randomly assigned to different groups. BPC 157, a stable gastric pentadecapeptide, has been used in clinical applications-specifically, in ulcerative colitis-and was successful in treating both external and internal fistulas.
Grgić, Tihomir, Grgić, Dora, Drmić, Domagoj, Zenko Sever, Anita, Petrović, Igor, Sučić, Mario, Kokot, Antonio, Kliček, Robert, Sever, Marko, Seiwerth, Sven, Sikirić, Predrag   +10 more
openaire   +2 more sources

Focus on Ulcerative Colitis: Stable Gastric Pentadecapeptide BPC 157

Current Medicinal Chemistry, 2012
Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects. BPC 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD) (PL 14736) so far only tested in clinical phase II, has a ...
P, Sikiric, S, Seiwerth, R, Rucman, B, Turkovic, D S, Rokotov, L, Brcic, M, Sever, R, Klicek, B, Radic, D, Drmic, S, Ilic, D, Kolenc, V, Stambolija, Z, Zoricic, H, Vrcic, B, Sebecic   +15 more
openaire   +2 more sources

Stable Gastric Pentadecapeptide BPC 157 as a Therapy of Severe Electrolyte Disturbances in Rats.

Current Neuropharmacology
This review explores the therapeutic potential of the stable gastric pentadecapeptide BPC 157 in addressing electrolyte imbalances, specifically hyperkalemia, hypokalemia, hypermagnesemia, and hyperlithemia.
M. Grubisic, S. Štrbe, I. Barišić, Dijana Balenovic, V. Stambolija, M. Lozić, Sanja Baršić Ostojić, Ivana Orešković, Helena Žižek, Klara Brčić, L. Coric, M. Starešinić, V. Blagaić, L. B. Orešković, Ž. Halle, Danijel Matek, Dragan Soldo, Boris Grizelj, A. B. Blagaic, A. Škrtić, P. Sikiric, S. Seiwerth   +21 more
semanticscholar   +1 more source

"СІРА ЗОНА" ФАРМАКОЛОГІЇ: ОГЛЯД ПЕПТИДНИХ БІОРЕГУЛЯТОРІВ ДЛЯ ВІДНОВЛЕННЯ ПІСЛЯ СПОРТИВНИХ ТРАВМ (BPC-157, TB-500)

PHYSICAL CULTURE AND SPORT: SCIENTIFIC PERSPECTIVE
The management of musculoskeletal injuries, particularly tendinopathies and ligament damage, remains a significant challenge in sports medicine. This is primarily due to the limited vascularization and low endogenous regenerative potential of connective ...
А. В. Чорномидз, Микола Кланца   +1 more
semanticscholar   +1 more source