Results 131 to 140 of about 342,766 (326)

A Stylised Model for Extreme Shocks: Four Moments of the Apocalypse [PDF]

open access: yes
We present a method for calculating the extreme tail quantiles, over arbitrary holding periods, of a continuous-time stochastic volatility model of the form proposed by Scott (1987) with correlation between the processes for volatility and price. The fat
Allan Brace, Mark Lauer, Milo Rado
core  

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

ATP synthase evolution on a cross-braced dated tree of life

open access: green, 2023
Tara Mahendrarajah   +10 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Maize brace root mechanics vary by whorl, genotype and reproductive stage [PDF]

open access: bronze, 2022
Ashley N. Hostetler   +5 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Effects of prophylactic ankle and knee braces on leg stiffness during hopping

open access: yesOpen Access Journal of Sports Medicine, 2017
Hiroaki Hobara, Satoru Hashizume, Yoshiyuki Kobayashi Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan Abstract: During human movement, the leg can be represented as a mechanical spring,
Hobara H, Hashizume S, Kobayashi Y
doaj  

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