Results 101 to 110 of about 30,916 (220)
ABSTRACT Introduction Brachytherapy is a widely accepted treatment for prostate cancer, in which subsequent radiation‐associated enteric‐type urethral adenocarcinoma is extremely rare. Case Presentation An 83‐year‐old man with a history of cholecystitis, appendicitis, and hyperlipidemia who had undergone brachytherapy 20 years earlier presented with ...
Yuki Tanaka +6 more
wiley +1 more source
The proposed sandwich total neoadjuvant treatment (TNT) strategy (NeoCT–CRT–NeoCT) represents a safe and effective therapeutic option for carefully selected patients with low‐risk distal locally advanced rectal cancer (LARC). By sequentially integrating induction chemotherapy, concurrent chemoradiotherapy, and consolidation chemotherapy, this approach ...
Shuang Liu +17 more
wiley +1 more source
Concurrent chemoradiotherapy plus immunotherapy (CICRT) promotes tumor microenvironment remodeling in locally advanced cervical cancer to enhance antitumor immunity. It reduces regulatory T cells and mitigates CD8+ T‐cell exhaustion while reprogramming macrophages toward a pro‐inflammatory phenotype. Furthermore, CICRT upregulates MHC‐II expression and
Yuhan Sheng +7 more
wiley +1 more source
Abstract Background Radiance is a Monte Carlo−based treatment planning software integrated into the Intrabeam system for 50‐kVp X‐rays intraoperative radiotherapy (IORT). Purpose This study evaluates Radiance accuracy in calculating absorbed dose in IORT of the breast including the effect of tissue heterogeneities.
Aurora Corso +7 more
wiley +1 more source
Macro Monte Carlo dose calculation for very high energy electron (VHEE) radiotherapy
Abstract Background Very high energy electron (VHEE) radiotherapy has gained growing interest owing to its potential to reach deep‐seated targets and induce FLASH effect. Dose calculations can be performed using analytical or Monte Carlo (MC) methods. Analytical approaches enable rapid dose computation but suffer from limited accuracy in heterogeneous ...
Chengchen Zhu +6 more
wiley +1 more source
Abstract Background Pre‐clinical in vivo characterization is a necessary step in the translation of novel radiotherapeutic interventions to clinical application. In vivo irradiations using a radioactive source like Ir‐192 are challenging due to steep dose gradients and absence of universally available applicators that do not require physical contact or
Daniel Cecchi +6 more
wiley +1 more source
Brachytherapy is the oldest radiotherapeutic modality and the first non- surgical oncologic therapy. It can be used in the treatment of a great variety of tumors. The major task of the treatment is to deliver cancerocidal doses of radiation to small volumes of tumor tissue, whilst producing minimal normal tissue toxicity.
Bokulić, Tomislav +4 more
openaire +2 more sources
Abstract Background FLASH radiotherapy requires further preclinical and clinical investigation to establish its biological effectiveness and define optimal beam parameters. In conventional (CONV) radiotherapy, redundant beam termination systems are a cornerstone ensuring patient safety, yet analogous safeguards for FLASH delivery are not well ...
Justin DeFrancisco +5 more
wiley +1 more source
Focal therapy using a novel cooled laser device for prostate cancer: early trial results
Objectives To determine the short‐term oncological results and safety of the ProFocal Laser Therapy for Prostate Tissue Ablation (PFLT‐PC) trial, the first phase II clinical trial of ProFocal® (Medlogical Innovations, Sydney, Australia), a novel, cooled laser focal therapy (cLFT) device for prostate cancer (PCa) treatment. Patients and Methods Men with
Jonathan Kam +17 more
wiley +1 more source

