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The role of bracken fern illudanes in bracken fern-induced toxicities

Mutation Research/Reviews in Mutation Research, 2019
Bracken fern is carcinogenic when fed to domestic and laboratory animals inducing bladder and ileal tumours and is currently classified as a possible human carcinogen by IARC. The carcinogenic illudane, ptaquiloside (PTQ) was isolated from bracken fern and is widely assumed to be the major bracken carcinogen. However, several other structurally similar
P.J. O’Connor   +3 more
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Carcinogenic Principles Isolated from Bracken Fern

CRC Critical Reviews in Toxicology, 1986
The carcinogenicity of bracken fern, Pteridium aquilinum, was demonstrated most clearly by the experiment of Evans and Mason in 1965. We have performed fractionation of the aqueous extract by means of the assay based on carcinogenicity and isolated an unstable norsesquiterpene glucoside of illudane type named ptaquiloside (PT). It was proved that PT is
Iwao Hirono, Elizabeth K. Weisburger
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Bracken fern poisoning

New Zealand Veterinary Journal, 1952
Abstract Extract Poisoning of cattle by bracken fern (Pteridium aquilinum) has long been a serious problem on some of the poorer land where eradication of bracken is difficult or uneconomic. The problem occurs also on some better-class land since not infrequently cattle are used to crush out the bracken in the first stages of development of the land or
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Bracken Fern Poisoning in Animals

2023
  The most prevalent poisonous plant species found in temperate and subtropical climates is bracken fern. Although young plants are said to be more toxic than older ones, plant material as a whole is typically toxic. Various active principles present in it have the potential to cause disease conditions in animals. The fully characterized toxic factors
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Passage of Bracken Fern Toxicity into Milk

Nature, 1972
BRACKEN (Pteridium aquilinum) and extracts of the plant have pluripotent carcinogenic and mutagenic properties, and if administered in sufficient concentration are acutely toxic to species as varied as mice and bovines1–9. The causative factor(s) of these different biological activities seem to be identical; they are produced by the same purified ...
I A, Evans   +2 more
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Separation of carcinogenic fraction of bracken fern

Cancer Letters, 1984
Isolation of the carcinogen in the boiling water extract of bracken fern was conducted by following the active principle with a carcinogenicity bioassay. Fractionation of the bracken extract was carried out using adsorption on resin (Amberlite XAD-2 and TOYOPEARL HW-40 (c] and organic solvent extraction.
Iwao Hirono   +10 more
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Physiological requirements for ciliary reactivation of bracken fern spermatozoids

Journal of Cell Science, 1980
ABSTRACT Physiological parameters affecting reactivated ciliary beat in spermatozoids of bracken fem (Pteridium aquilinum) were studied using a Triton/glycerol permeabilized cell model system. Reactivation frequencies of polylysine-tethered cells equalled in vivo rates at neutral pH. Frequency was dependent on ATP and Mg!+ concentration,
S M, Wolniak, W Z, Cande
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Chromsome aberrations in cattle raised on bracken fern pasture

Experientia, 1988
Thirteen cows maintained on natural bracken fern (Pteridium aquilinum) were analyzed cytogenetically. The frequency of structural chromosome aberrations detected in peripheral blood cells was significantly higher when compared to that detected in animals raised on pasture containing no bracken fern.
J W, Moura   +5 more
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Gametophyte formation in bracken fern root cultures

Canadian Journal of Botany, 1969
Excised roots of the bracken fern (Pteridium aquilinum (L.) Kuhn) have been continuously subcultured in various growth supporting media. The formation of gametophytes on the roots (apospory) occurs in three instances: on intact sporelings in culture, in aged growing root cultures after growth of the roots has ceased, and at an earlier time on excised ...
Marian H. Munroe, Ian M. Sussex
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Effect of storage on carcinogenic activity of bracken fern

Cancer Letters, 1981
Effect of storage on carcinogenic activity of bracken fern was examined with inbred strain ACI rats of both sexes. The experiment was broken down into 3 groupings: Group I received a diet containing fresh dry bracken powder: Group II received a diet which contained the same dry bracken powder used in Group I but preserved for 1 year at 4 degrees C ...
T, Kawai   +4 more
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