Results 281 to 290 of about 5,914,322 (327)

Marine trophic architecture and hidden ecological connections in the Strait of Magellan: keystone species and ecosystem resilience

open access: yesOikos, EarlyView.
Understanding the ecological implications of species coexistence is central to biodiversity studies and to identify environmental and anthropogenic drivers of ecosystem dynamics, where ecological network analysis offers valuable insights. This study examines the complexity, structure, and potential responses to disturbances of the Strait of Magellan's ...
Claudia D. Andrade   +4 more
wiley   +1 more source

Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake

open access: yesChemistryOpen, EarlyView.
In this article, proteolysis targeting chimeras (PROTACs) bearing a polyamine linker capable of crossing cancer cell membranes via the polyamine transport system are synthesized and evaluated. The results provide valuable insights for the design of PROTACs with enhanced cellular uptake efficiency.
Yanran Liu   +6 more
wiley   +1 more source

Key gaps remain in the definition and application of keystone species concepts for fisheries management: A systematic scoping review

open access: yesPeople and Nature, EarlyView.
Abstract A keystone species is one whose influence is disproportionate to its abundance, the absence of which would change the dynamics of an ecological or human community. Despite its widespread use in the scientific literature, there is a limited understanding of how the keystone concept is defined or measured, or applied in practice, and especially ...
Natasha R. Serrao   +5 more
wiley   +1 more source

Selectively Cleavable Silicone Elastomers Based on Acetal Cross‐Linkers: Synthesis, Properties, and Study of Chemical Degradation

open access: yesJournal of Polymer Science, EarlyView.
A novel silicone elastomer based on selectively cleavable acetal cross‐linkers incorporated by hydrosilylation was developed. Different acetal cross‐linkers were synthesized and introduced into a silicone formulation of vinyl‐terminated PDMS and tetrakis(dimethylsiloxy)silane using Karstedt's catalyst.
Julian Beier   +3 more
wiley   +1 more source

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