Results 41 to 50 of about 83,150 (251)

The Role of Electrophysiologic Study in Device Selection for Leadless Atrial Pacing [PDF]

Texas Heart Institute Journal
The AVEIR DR (Abbott Medical) was the first dual-chamber leadless pacing system approved by the US Food and Drug Administration. Many patients with sinus node dysfunction have physiologically normal atrioventricular conduction, so an atrial-only pacing ...
Joshua R. Hirsch, MD, Jordan M. Gales, MD, Irakli Giorgberidze, MD, Hamid Afshar, MD   +3 more
doaj   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Breaking the BRASH Cycle: Early Hemodialysis Saving a Chronic Kidney Disease Patient with Severe Bradycardia

Journal of the Practice of Cardiovascular Sciences
BRASH syndrome – a clinical entity defined by bradycardia, renal failure, AV nodal blockade, shock, and hyperkalemia – represents a dangerous, self-perpetuating cycle that can rapidly lead to hemodynamic instability and multiorgan dysfunction.
Sanchit Chhabra, Sunil Kumar, Anjalee Anil Chiwhane, Utkarsh Pradeep, Gautam Bedi   +4 more
doaj   +1 more source

Cardiovascular Organoids With Adjustable Endothelial Composition via SOX17‐Engineered hPSCs

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Organoids are considered a novel modeling platform for studying human biology and advancing health research. With the ability to demonstrate complex 3D structure and multicellular interactions, organoids have advanced studies in all major organs as a reliable model.
Po‐Yu Liang, Gyuhyung Jin, Nathan R. Petrucci, Xiaojun Lance Lian, Xiaoping Bao   +4 more
wiley   +1 more source

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source

Characterizing the repeatability of cardiovascular responses to hypoxic apneas in adults

Physiological Reports
Apneas performed during hypoxia cause pronounced bradycardia and cardiac arrhythmias. What remains unclear is the intraindividual consistency of these responses.
Desmond A. Young, Benjamin R. O'Croinin, Mackenzie I. Farris, Sean vanDiepen, Craig D. Steinback   +4 more
doaj   +1 more source

Atypical Presentation of Massive Pulmonary Embolism, a Case Report

Archives of Academic Emergency Medicine, 2018
The lack of pathognomonic signs and symptoms makes the diagnosis of pulmonary embolism (PE) difficult. Here, we report a case of a 42-year-old man presented to the emergency department with worsening epigastric pain, hypotension, frank bradycardia, and ...
Alireza Majidi, Sadrollah Mahmoodi, Alireza Baratloo, Sahar Mirbaha   +3 more
doaj   +1 more source

Implementation of guideline‐recommended medical therapy for patients with heart failure in Europe

ESC Heart Failure, Volume 12, Issue 2, Page 790-798, April 2025.
Abstract Physicians' adherence to guideline‐recommended heart failure (HF) treatment remains suboptimal, especially regarding the target doses. In particular, there is evidence that non‐cardiologists are less compliant with HF guideline recommendations. This is likely to have a detrimental impact on patients' survival, readmissions and quality of life.
Maurizio Volterrani, Petar Seferovic, Gianluigi Savarese, Ilaria Spoletini, Egidio Imbalzano, Antoni Bayes‐Genis, Ewa Jankowska, Michele Senni, Marco Metra, Ovidiu Chioncel, Andrew J. S. Coats, Giuseppe M. C. Rosano   +11 more
wiley   +1 more source

Effects of remimazolam, cipepofol and propofol on circulation during induction period of general anesthesia

Zhongguo linchuang yanjiu
Objective To observe the effects of remimazolam, cipepofol, and propofol on hemodynamics, blood glucose, and lactate levels during general anesthesia induction. Methods A total of 126 elective surgery patients at the Second Affiliated Hospital of Nanjing
ZHANG Qing, HONG Hong, AN Jing, JI Muhuo, PENG Hui
doaj   +1 more source