Results 191 to 200 of about 2,163,819 (261)

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

BrainSTEM: A single-cell multiresolution fetal brain atlas reveals transcriptomic fidelity of human midbrain cultures. [PDF]

Sci Adv
Toh HSY, Xu L, Chen C, Yang P, Sun AX, Ouyang JF.   +5 more
europepmc   +1 more source

Supervised Learning With Perceptual Similarity for Multimodal Gene Expression Registration of a Mouse Brain Atlas. [PDF]

Front Neuroinform, 2021
Krepl J, Casalegno F, Delattre E, Erö C, Lu H, Keller D, Rodarie D, Markram H, Schürmann F.   +8 more
europepmc   +1 more source

MIIP Inhibits Colorectal Cancer Progression by Modulating Neutrophils Infiltration and Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li, Jia Deng, Lin Sun, Shihui Wang, Huizhi Li, Jing Chen, Lipan Zhao, Xilin Shen, Yan Sun   +8 more
wiley   +1 more source

A genetically informed brain atlas for enhancing brain imaging genomics. [PDF]

Nat Commun
Bao J, Wen J, Chang C, Mu S, Chen J, Shivakumar M, Cui Y, Erus G, Yang Z, Yang S, Wen Z, Alzheimer’s Disease Neuroimaging Initiative, Zhao Y, Kim D, Duong-Tran D, Saykin AJ, Zhao B, Davatzikos C, Long Q, Shen L.   +19 more
europepmc   +1 more source

Quantitative assessment of inter-individual variability in fMRI-based human brain atlas. [PDF]

Quant Imaging Med Surg, 2021
Wang H, Sun J, Cui D, Wang X, Jin J, Li Y, Liu Z, Yin T.   +7 more
europepmc   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

First oxygen-oxygen collisions recorded by the ATLAS Experiment

Collision events recorded by the ATLAS experiment on 5 July 2025, when stable beams of oxygen, colliding at a centre-of-mass energy per nucleon pair of 5.36 TeV, were delivered to ATLAS by the ...
ATLAS Collaboration
core  

Patient‐Mounted Neuro Optical Coherence Tomography for Targeted Minimally Invasive Micro‐Resolution Volumetric Imaging in Brain In Vivo

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Herein, a patient‐mounted neuro optical coherence tomography system that integrates a 5 degrees‐of‐freedom skull‐mounted robot (Skullbot) with a 0.6 mm neuroendoscope for targeted, minimally invasive deep brain imaging, is developed. The system offers high‐resolution imaging with precise deployment, demonstrated through successful tumor imaging in a ...
Chao Xu, Zhiwei Fang, Huxin Gao, Tinghua Zhang, Tao Zhang, Peng Liu, Hongliang Ren, Wu Yuan   +7 more
wiley   +1 more source

Topic modeling analysis of the Allen Human Brain Atlas. [PDF]

Sci Rep
Pizzini L, Valle F, Osella M, Caselle M.
europepmc   +1 more source