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Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities [PDF]
Biomedicines, 2023 Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative ...
Vicente Javier Clemente-Suárez +9 more
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Editorial: Optical imaging in neuroscience and brain disease [PDF]
Frontiers in Neuroscience, 2023 Guanglei Zhang +4 more
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Journal of Immunology Research, 2022 Vascular cognitive impairment (VCI) has emerged as the second major disease responsible for dementia, and there is still a lack of effective treatment methods for this disorder to date.
Tingliang Gong +8 more
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Parkinsonism mutations in DNAJC6 cause lipid defects and neurodegeneration that are rescued by Synj1
npj Parkinson's Disease, 2023 Recent evidence links dysfunctional lipid metabolism to the pathogenesis of Parkinson’s disease, but the mechanisms are not resolved. Here, we generated a new Drosophila knock-in model of DNAJC6/Auxilin and find that the pathogenic mutation causes ...
Julie Jacquemyn +10 more
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An overview of seizures and epilepsy in rabbits: etiological differences and clinical management [PDF]
Науковий вісник ветеринарної медицини, 2021 World Health Organization data suggest that neurological disorders are an important and growing cause of morbidity. One of the most common neurological disorder affecting people is epilepsy. Many companion animal neurological diseases share epidemiologic,
Gülersoy E., İyigün S.S., Erol B.B.
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VHHs as tools for therapeutic protein delivery to the central nervous system
Fluids and Barriers of the CNS, 2022 Background The blood brain barrier (BBB) limits the therapeutic perspective for central nervous system (CNS) disorders. Previously we found an anti-mouse transferrin receptor (TfR) VHH (Nb62) that was able to deliver a biologically active neuropeptide ...
Yessica Wouters +5 more
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Brain Sciences, 2022 Resting-state functional magnetic resonance imaging (rs-fMRI) has been used to construct functional connectivity (FC) in the brain for the diagnosis and analysis of brain disease.
Libin Gao +6 more
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Molecular Systems Biology, 2020 Single‐cell technologies allow measuring chromatin accessibility and gene expression in each cell, but jointly utilizing both layers to map bona fide gene regulatory networks and enhancers remains challenging.
Carmen Bravo González‐Blas +13 more
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Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
EMBO Molecular Medicine, 2020 Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how subthreshold risk loci translate into relevant disease pathways is unknown.
Annerieke Sierksma +10 more
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Genetic Defects and Pro-inflammatory Cytokines in Parkinson's Disease
Frontiers in Neurology, 2021 Parkinson's disease (PD) is a movement disorder attributed to the loss of dopaminergic (DA) neurons mainly in the substantia nigra pars compacta. Motor symptoms include resting tremor, rigidity, and bradykinesias, while non-motor symptoms include ...
Albert Frank Magnusen +4 more
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