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Neuroinflammation and Brain Disease. [PDF]
BMC Neurol, 2023 AbstractStarting from the perspective of an immune-privileged site, our knowledge of the inflammatory processes within the central nervous system has increased rapidly over the last 30 years, leading to a rather puzzling picture today. Of particular interest is the emergence of disease- and injury-specific inflammatory responses within the brain, which
Bersano A, Engele J, Schäfer MKE.
europepmc +4 more sources
The Potential of the Human Connectome as a Biomarker of Brain Disease [PDF]
Frontiers in Human Neuroscience 7:484, 2013, 2013 The human connectome at the level of fiber tracts between brain regions has been shown to differ in patients with brain disorders compared to healthy control groups. Nonetheless, there is a potentially large number of different network organizations for individual patients that could lead to cognitive deficits prohibiting correct diagnosis.
Kaiser, Marcus
arxiv +4 more sources
Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities [PDF]
Biomedicines, 2023 Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative ...
Vicente Javier Clemente-Suárez +9 more
doaj +2 more sources
Case of Organic Disease of the Brain [PDF]
The American Journal of the Medical Sciencesn ...
John Ware
openalex +7 more sources
Editorial: Optical imaging in neuroscience and brain disease [PDF]
Frontiers in Neuroscience, 2023 Guanglei Zhang +4 more
doaj +2 more sources
Journal of Immunology Research, 2022 Vascular cognitive impairment (VCI) has emerged as the second major disease responsible for dementia, and there is still a lack of effective treatment methods for this disorder to date.
Tingliang Gong +8 more
doaj +1 more source
Reprogramming the diseased brain [PDF]
Nature Biotechnology, 2017 Direct conversion of astrocytes to dopamine neurons in vivo offers fresh optimism for the development of improved Parkinson's ...
Stephen B. Dunnett +1 more
openaire +3 more sources
Parkinsonism mutations in DNAJC6 cause lipid defects and neurodegeneration that are rescued by Synj1
npj Parkinson's Disease, 2023 Recent evidence links dysfunctional lipid metabolism to the pathogenesis of Parkinson’s disease, but the mechanisms are not resolved. Here, we generated a new Drosophila knock-in model of DNAJC6/Auxilin and find that the pathogenic mutation causes ...
Julie Jacquemyn +10 more
doaj +1 more source
VHHs as tools for therapeutic protein delivery to the central nervous system
Fluids and Barriers of the CNS, 2022 Background The blood brain barrier (BBB) limits the therapeutic perspective for central nervous system (CNS) disorders. Previously we found an anti-mouse transferrin receptor (TfR) VHH (Nb62) that was able to deliver a biologically active neuropeptide ...
Yessica Wouters +5 more
doaj +1 more source