Results 1 to 10 of about 2,886,262 (322)
Neuroinflammation and Brain Disease. [PDF]
BMC Neurol, 2023 AbstractStarting from the perspective of an immune-privileged site, our knowledge of the inflammatory processes within the central nervous system has increased rapidly over the last 30 years, leading to a rather puzzling picture today. Of particular interest is the emergence of disease- and injury-specific inflammatory responses within the brain, which
Bersano A, Engele J, Schäfer MKE.
europepmc +4 more sources
Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities [PDF]
Biomedicines, 2023 Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative ...
Vicente Javier Clemente-Suárez +9 more
doaj +2 more sources
Editorial: Optical imaging in neuroscience and brain disease [PDF]
Frontiers in Neuroscience, 2023 Guanglei Zhang +4 more
doaj +2 more sources
An overview of seizures and epilepsy in rabbits: etiological differences and clinical management [PDF]
Науковий вісник ветеринарної медицини, 2021 World Health Organization data suggest that neurological disorders are an important and growing cause of morbidity. One of the most common neurological disorder affecting people is epilepsy. Many companion animal neurological diseases share epidemiologic,
Gülersoy E., İyigün S.S., Erol B.B.
doaj +1 more source
Journal of Immunology Research, 2022 Vascular cognitive impairment (VCI) has emerged as the second major disease responsible for dementia, and there is still a lack of effective treatment methods for this disorder to date.
Tingliang Gong +8 more
doaj +1 more source
Parkinsonism mutations in DNAJC6 cause lipid defects and neurodegeneration that are rescued by Synj1
npj Parkinson's Disease, 2023 Recent evidence links dysfunctional lipid metabolism to the pathogenesis of Parkinson’s disease, but the mechanisms are not resolved. Here, we generated a new Drosophila knock-in model of DNAJC6/Auxilin and find that the pathogenic mutation causes ...
Julie Jacquemyn +10 more
doaj +1 more source
VHHs as tools for therapeutic protein delivery to the central nervous system
Fluids and Barriers of the CNS, 2022 Background The blood brain barrier (BBB) limits the therapeutic perspective for central nervous system (CNS) disorders. Previously we found an anti-mouse transferrin receptor (TfR) VHH (Nb62) that was able to deliver a biologically active neuropeptide ...
Yessica Wouters +5 more
doaj +1 more source
Genetic Defects and Pro-inflammatory Cytokines in Parkinson's Disease
Frontiers in Neurology, 2021 Parkinson's disease (PD) is a movement disorder attributed to the loss of dopaminergic (DA) neurons mainly in the substantia nigra pars compacta. Motor symptoms include resting tremor, rigidity, and bradykinesias, while non-motor symptoms include ...
Albert Frank Magnusen +4 more
doaj +1 more source
Contribution of Axon Initial Segment Structure and Channels to Brain Pathology
Cells, 2023 Brain channelopathies are a group of neurological disorders that result from genetic mutations affecting ion channels in the brain. Ion channels are specialized proteins that play a crucial role in the electrical activity of nerve cells by controlling ...
Juan José Garrido
doaj +1 more source
Applications of nanobodies in brain diseases
Frontiers in Immunology, 2022 Nanobodies are antibody fragments derived from camelids, naturally endowed with properties like low molecular weight, high affinity and low immunogenicity, which contribute to their effective use as research tools, but also as diagnostic and therapeutic ...
Fang Zheng +7 more
doaj +1 more source