Results 91 to 100 of about 2,886,262 (322)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Vitamin B12 as a cholinergic system modulator and blood brain barrier integrity restorer in Alzheimer's disease

, 2022
Nesrine S. El-Mezayen, Rehab.A. Abd el Moneim, Safaa H. El‐Rewini   +2 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling

Journal of Neuroinflammation, 2019
Background The FDA-approved small-molecule drug dasatinib is currently used as a treatment for chronic myeloid leukemia (CML). However, the effects of dasatinib on microglial and/or astrocytic neuroinflammatory responses and its mechanism of action have ...
Ka-Young Ryu, Hyun-ju Lee, Hanwoong Woo, Ri-Jin Kang, Kyung-Min Han, HyunHee Park, Sang Min Lee, Ju-Young Lee, Yoo Joo Jeong, Hyun-Wook Nam, Youngpyo Nam, Hyang-Sook Hoe   +11 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Altered Brain Serotonin Transporter and Associated Glucose Metabolism in Alzheimer Disease [PDF]

, 2009
Yasuomi Ouchi, Etsuji Yoshikawa, Masami Futatsubashi, Shunsuke Yagi, Takatoshi Ueki, Kazuhiko Nakamura   +5 more
openalex   +1 more source

MOG antibody associated disease (MOGAD) presenting with extensive brain stem encephalitis: A case report

, 2022
Elisabeth Olbert, Cornelia Brunner, Naela Alhani, Christian Našel, Walter Struhal   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Gradual Variation-Based Dual-Stream Deep Learning for Spatial Feature Enhancement With Dimensionality Reduction in Early Alzheimer’s Disease Detection

IEEE Access
Alzheimer’s disease (AD) is one of the most common neurological brain disorders, developing gradually and primarily causing the deterioration of brain function, leading to memory loss and behavioral changes.
Najmul Hassan, Abu Saleh Musa Miah, Taro Suzuki, Jungpil Shin   +3 more
doaj   +1 more source

Microvascular Disease in Type 1 Diabetes Alters Brain Activation [PDF]

, 2006
Alette M. Wessels, Serge A.R.B. Rombouts, Suat Şimşek, Joost P.A. Kuijer, Piet J. Kostense, Frederik Barkhof, Philip Scheltens, Frank J. Snoek, Robert J. Heine   +8 more
openalex   +1 more source