Results 121 to 130 of about 2,886,262 (322)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Editorial: Computational Neuroimage Analysis Tools for Brain (Diseases) Biomarkers

Frontiers in Neuroscience, 2022
Diana M. Sima, Diana M. Sima, Meritxell Bach Cuadra, Meritxell Bach Cuadra, Meritxell Bach Cuadra, Tim B. Dyrby, Tim B. Dyrby, Koen Van Leemput, Koen Van Leemput   +8 more
doaj   +1 more source

Applications of deep learning in magnetic resonance imaging–based diagnosis of brain diseases

工程科学学报
As brain diseases can severely affect society, studies on the diagnosis of brain diseases are gaining importance. China is focused on counteracting the issues in brain disease diagnosis and treatment.
Jianchun ZHU, Jiaxin WEI, Junbin MAO, Kun LIU, Hongyu HE, Jin LIU   +5 more
doaj   +1 more source

In Utero Brain Growth Matters for Fetuses With Congenital Heart Disease [PDF]

, 2022
Mike Seed, Catherine Limperopoulos
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Editorial: Somatic genomic mosaicism & human disease

Frontiers in Genetics, 2022
Ivan Y. Iourov, Ivan Y. Iourov, Ivan Y. Iourov, Henry H. Heng, Henry H. Heng   +4 more
doaj   +1 more source

Hyper-Ordinal Pattern: Measuring High-Order Connection Relationship in Brain Disease Networks

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Brain hyper-networks as a kind of hypergraph for brain network analysis, describing the high-order interactions among brain regions, have been extensively utilized in research on brain diseases such as mild cognitive impairment (MCI) and Alzheimer’
Tianyu Du, Kai Ma, Xibei Yang, Daoqiang Zhang   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The measles virus matrix F50S mutation from a lethal case of subacute sclerosing panencephalitis promotes receptor-independent neuronal spread

Journal of Virology
Subacute sclerosing panencephalitis (SSPE) is a lethal neurological disorder occurring several years after measles. Reconstruction of the evolution of the measles virus (MeV) genome in an SSPE case suggested that the matrix (M) protein mutation M-F50S ...
Iris Yousaf, Luke Domanico, Toshihiko Nambara, Kalpana Yadav, Lauren K. Kelly, Jorge Trejo-Lopez, Wun-Ju Shieh, Paul A. Rota, Patricia Devaux, Takahisa Kanekiyo, Matthew P. Taylor, Roberto Cattaneo   +11 more
doaj   +1 more source