Results 11 to 20 of about 2,886,262 (322)
Molecular Systems Biology, 2020 Single‐cell technologies allow measuring chromatin accessibility and gene expression in each cell, but jointly utilizing both layers to map bona fide gene regulatory networks and enhancers remains challenging.
Carmen Bravo González‐Blas +13 more
doaj +1 more source
Frontiers in Synaptic Neuroscience, 2021 Auxiliary α2δ subunits of voltage-gated calcium channels modulate channel trafficking, current properties, and synapse formation. Three of the four isoforms (α2δ-1, α2δ-2, and α2δ-3) are abundantly expressed in the brain; however, of the available ...
Stefanie M. Geisler +8 more
doaj +1 more source
Identification and in vivo characterization of a brain-penetrating nanobody
Fluids and Barriers of the CNS, 2020 Background Preclinical models to determine blood to brain transport ability of therapeutics are often ambiguous. In this study a method is developed that relies on CNS target-engagement and is able to rank brain-penetrating capacities. This method led to
Y Wouters +3 more
doaj +1 more source
Reprogramming the diseased brain [PDF]
Nature Biotechnology, 2017 Direct conversion of astrocytes to dopamine neurons in vivo offers fresh optimism for the development of improved Parkinson's ...
Dunnett, Stephen, Rosser, Anne
openaire +2 more sources
Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
EMBO Molecular Medicine, 2020 Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how subthreshold risk loci translate into relevant disease pathways is unknown.
Annerieke Sierksma +10 more
doaj +1 more source
THE PSYCHOMOTOR THEORY OF HUMAN MIND [PDF]
, 2007 This study presents a new theory to explain the neural origins of human mind. This is the psychomotor theory. The author briefly analyzed the historical development of the mind-brain theories.
TAN, Prof. Dr. Uner
core +1 more source
Identifying progressive imaging genetic patterns via multi-task sparse canonical correlation analysis: a longitudinal study of the ADNI cohort [PDF]
, 2019 Motivation Identifying the genetic basis of the brain structure, function and disorder by using the imaging quantitative traits (QTs) as endophenotypes is an important task in brain science.
Du, Lei +7 more
core +1 more source
Alzheimer and vascular brain disease: Senile dementia. [PDF]
, 2015 Alois Alzheimer is best known for his description of a novel disease, subsequently named after him. However, his wide range of interests also included vascular brain diseases.
Engelhardt, Eliasz, Grinberg, Lea T
core +2 more sources
Brain Sciences, 2022 Resting-state functional magnetic resonance imaging (rs-fMRI) has been used to construct functional connectivity (FC) in the brain for the diagnosis and analysis of brain disease.
Libin Gao +6 more
doaj +1 more source
Parkinson's disease dementia: a neural networks perspective. [PDF]
, 2015 In the long-term, with progression of the illness, Parkinson's disease dementia affects up to 90% of patients with Parkinson's disease. With increasing life expectancy in western countries, Parkinson's disease dementia is set to become even more ...
Foltynie, T, Gratwicke, J, Jahanshahi, M
core +1 more source