Results 21 to 30 of about 2,638,617 (370)

Novel Noninvasive Brain Disease Detection System Using a Facial Image Sensor

Sensors, 2017
Brain disease including any conditions or disabilities that affect the brain is fast becoming a leading cause of death. The traditional diagnostic methods of brain disease are time-consuming, inconvenient and non-patient friendly.
Ting Shu, Bob Zhang, Yuan Yan Tang
doaj   +1 more source

Matrix metalloproteinases at key junctions in the pathomechanism of stroke [PDF]

, 2011
Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Amento, Ang, Asahi, Asahi, Barkho, Bergers, Bini, Cao, Cardone, Chinopoulos, Cunningham, Denker, Dong, Fabunmi, Fisher, Frisch, Galis, Galis, Galis, Galis, Gidday, Godin, Gross, Gu, Gu, Gurney, Haas, Haddad, Halliwell, Hamann, Harkness, Herman, Hornig, Hyslop, Itoh, Kumura, Langton, Lapchak, Larsen, Lee, Lelongt, Loftus, Lucivero, Luttun, McQuibban, Meredith, Montaner, Montaner, Nagase, Nagel, Nagy, Nagy, Nikkari, Pagenstecher, Qi, Rajagopalan, Ramos, Rekhter, Rolfe, Romanic, Rosell, Rosenberg, Rosenberg, Rosenberg, Rosenberg, Sarén, Sato, Seo, Shrivastava, Shubayev, Siao, Sole, Sottrup, Sternlicht, Strongin, Sukhova, Suzuki, Suzuki, Svedin, Tsuji, Turner, Van, Vogel, Wang, Wang, Webersinke, Yepes, Ying, Zhang, Zhang, Zhang, Zhao   +91 more
core   +1 more source

"It's a brain disease" [PDF]

Psychiatric Services, 1997
T elling me that I have a brain disease and that I should take medication does not solve my problems. When I was first given the label of “psychotic,” I’m not sure it really mattered to me what had caused it. What I heard was you telling me that I had a chronic disease.
openaire   +3 more sources

RNAs in Brain and Heart Diseases [PDF]

International Journal of Molecular Sciences, 2020
In the era of single-cell analysis, one always has to keep in mind the systemic nature of various diseases and how these diseases could be optimally studied. Comorbidities of the heart in neurological diseases as well as of the brain in cardiovascular diseases are prevalent, but how interactions in the brain–heart axis affect disease development and ...
Beis, Dimitris, Zerr, Inga, Martelli, Fabio, Doehner, Wolfram, Devaux, Yvan, Beis, Dimitris; Zebrafish Disease Models lab, Center for Experimental Surgery Clinical and Translational Research, Biomedical Research Foundation Academy of Athens, 11527 Athens, Greece, dbeis@bioacademy.gr, Zerr, Inga; Department of Neurology, Clinical Dementia Centre and DZNE, University Medical School, Georg-August University, 37075 Göttingen, Germany, ingazerr@med.uni-goettingen.de, Martelli, Fabio; Molecular Cardiology Laboratory, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy, Fabio.Martelli@grupposandonato.it, Doehner, Wolfram; Department of Cardiology (Virchow Klinikum), BIH-Center for Regenerative Therapies, and Center for Stroke Research Berlin Charité-Universitätsmedizin, 13353 Berlin, Germany, wolfram.doehner@charite.de, Devaux, Yvan; Cardiovascular Research Unit, Department of Population Health, Luxembourg Institute of Health, L-1445 Strassen, Luxembourg, yvan.devaux@lih.lu   +9 more
openaire   +4 more sources

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

EMBO Molecular Medicine, 2020
Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how subthreshold risk loci translate into relevant disease pathways is unknown.
Annerieke Sierksma, Ashley Lu, Renzo Mancuso, Nicola Fattorelli, Nicola Thrupp, Evgenia Salta, Jesus Zoco, David Blum, Luc Buée, Bart De Strooper, Mark Fiers   +10 more
doaj   +1 more source

Gene Therapy Tools for Brain Diseases

Frontiers in Pharmacology, 2019
Neurological disorders affecting the central nervous system (CNS) are still incompletely understood. Many of these disorders lack a cure and are seeking more specific and effective treatments.
Selene Ingusci, Gianluca Verlengia, Gianluca Verlengia, Marie Soukupova, Silvia Zucchini, Silvia Zucchini, Michele Simonato, Michele Simonato   +7 more
doaj   +1 more source

Alzheimer and vascular brain disease: Senile dementia. [PDF]

, 2015
Alois Alzheimer is best known for his description of a novel disease, subsequently named after him. However, his wide range of interests also included vascular brain diseases.
Engelhardt, Eliasz, Grinberg, Lea T
core   +2 more sources

Applications of neuroimaging to disease-modification trials in Alzheimer's disease. [PDF]

, 2009
Critical to development of new therapies for Alzheimer's disease (AD) is the ability to detect clinical or pathological change over time. Clinical outcome measures typically used in therapeutic trials have unfortunately proven to be relatively variable ...
Aisen, Paul S, Alzheimer's Disease Neuroimaging Initiative, Brewer, James B, Chen, Kewei, Donohue, Michael, Fleisher, Adam S   +5 more
core   +2 more sources

Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

Nature Communications, 2023
There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings.
Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz   +13 more
doaj   +1 more source

Brain Diffuser: An End-to-End Brain Image to Brain Network Pipeline [PDF]

arXiv, 2023
Brain network analysis is essential for diagnosing and intervention for Alzheimer's disease (AD). However, previous research relied primarily on specific time-consuming and subjective toolkits. Only few tools can obtain the structural brain networks from brain diffusion tensor images (DTI).
arxiv