Results 21 to 30 of about 1,457,914 (292)
Identification and in vivo characterization of a brain-penetrating nanobody
Fluids and Barriers of the CNS, 2020 Background Preclinical models to determine blood to brain transport ability of therapeutics are often ambiguous. In this study a method is developed that relies on CNS target-engagement and is able to rank brain-penetrating capacities. This method led to
Y Wouters +3 more
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Applications of nanobodies in brain diseases
Frontiers in Immunology, 2022 Nanobodies are antibody fragments derived from camelids, naturally endowed with properties like low molecular weight, high affinity and low immunogenicity, which contribute to their effective use as research tools, but also as diagnostic and therapeutic ...
Fang Zheng +7 more
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Frontiers in Synaptic Neuroscience, 2021 Auxiliary α2δ subunits of voltage-gated calcium channels modulate channel trafficking, current properties, and synapse formation. Three of the four isoforms (α2δ-1, α2δ-2, and α2δ-3) are abundantly expressed in the brain; however, of the available ...
Stefanie M. Geisler +8 more
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Is Addiction a Brain Disease? [PDF]
Neuroethics, 2016 Where does normal brain or psychological function end, and pathology begin? The line can be hard to discern, making disease sometimes a tricky word. In addiction, normal 'wanting' processes become distorted and excessive, according to the incentive-sensitization theory.
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Gene Therapy Tools for Brain Diseases
Frontiers in Pharmacology, 2019 Neurological disorders affecting the central nervous system (CNS) are still incompletely understood. Many of these disorders lack a cure and are seeking more specific and effective treatments.
Selene Ingusci +7 more
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Novel Noninvasive Brain Disease Detection System Using a Facial Image Sensor
Sensors, 2017 Brain disease including any conditions or disabilities that affect the brain is fast becoming a leading cause of death. The traditional diagnostic methods of brain disease are time-consuming, inconvenient and non-patient friendly.
Ting Shu, Bob Zhang, Yuan Yan Tang
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Nature Communications, 2022 In this work, Louros et al. uncover a rule book for interactions of amyloids with other proteins. This grammar was shown to promote cellular spreading of tau aggregates in cells, but can also be harvested to develop structure-based aggregation blockers.
Nikolaos Louros +12 more
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Addiction and the Brain-Disease Fallacy [PDF]
Frontiers in Psychiatry, 2014 From Brainwashed: The Seductive Appeal of Mindless Neuroscience by Sally Satel and Scott Lilienfeld, copyright © 2013. Reprinted by permission of Basic Books, a member of The Perseus Books Group. The notion that addiction is a "brain disease" has become widespread and rarely challenged.
Satel, S, Lilienfeld, SO
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EMBO Molecular Medicine, 2023 Cognitive decline is a common pathological outcome during aging, with an ill‐defined molecular and cellular basis. In recent years, the concept of inflammaging, defined as a low‐grade inflammation increasing with age, has emerged.
Pierre Lemaitre +10 more
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Brain MRI in Parkinson's disease [PDF]
Frontiers in Bioscience, 2014 In this review article, conventional brain MRI and advanced MRI techniques in Parkinson`s disease (PD) are discussed, with emphasis on clinical relevance. Conventional brain MRI sequences generally demonstrate limited abnormalities specific for PD and in clinical practice brain MRI is mainly used to exclude other pathology.
Meijer, F.J.A. +3 more
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