Results 81 to 90 of about 2,638,617 (370)
Adversarial Learning Based Structural Brain-network Generative Model for Analyzing Mild Cognitive Impairment [PDF]
arXiv, 2022 Mild cognitive impairment(MCI) is a precursor of Alzheimer's disease(AD), and the detection of MCI is of great clinical significance. Analyzing the structural brain networks of patients is vital for the recognition of MCI. However, the current studies on structural brain networks are totally dependent on specific toolboxes, which is time-consuming and ...
arxiv
Why musical memory can be preserved in advanced Alzheimer's disease [PDF]
, 2015 Musical memory is relatively preserved in Alzheimer's disease and other dementias. In a 7 Tesla functional MRI study employing multi-voxel pattern analysis, Jacobsen et al.
Chételat, Gael +4 more
core +2 more sources
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source
Clinical utility of cerebrospinal fluid biomarkers measured by LUMIPULSE® system
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1898-1909, December 2022., 2022 Abstract Objectives Cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are well‐established in research settings, but their use in routine clinical practice remains a largely unexploited potential. Here, we examined the relationship between CSF biomarkers, measured by a fully automated immunoassay platform, and brain β‐amyloid (Aβ ...
Hisashi Nojima +9 more
wiley +1 more source
Long non-coding RNAs in brain tumors: roles and potential as therapeutic targets
Journal of Hematology & Oncology, 2021 Brain tumors are associated with adverse outcomes despite improvements in radiation therapy, chemotherapy, and photodynamic therapy. However, treatment approaches are evolving, and new biological phenomena are being explored to identify the appropriate ...
Sung-Hyun Kim +3 more
doaj +1 more source
BrainNetDiff: Generative AI Empowers Brain Network Generation via Multimodal Diffusion Model [PDF]
arXiv, 2023 Brain network analysis has emerged as pivotal method for gaining a deeper understanding of brain functions and disease mechanisms. Despite the existence of various network construction approaches, shortcomings persist in the learning of correlations between structural and functional brain imaging data.
arxiv
Dendritic cells in brain diseases
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2016 Authors receive financial support by the European Community (FP7-PEOPLE-2013-ITN-n°07962, supporting M.G.; the ERA-NET program PRI-PIMNEU-2011-1342; and FP7-HEALTH-F2-2011-n°278850); the Werner-Otto-Stiftung (17/86, supporting S.B.); the University of Hamburg (NWF-15/07); and the Spanish Ministry of Economy MINECO (SAF2014-56279)
Peter Ludewig +7 more
openaire +5 more sources
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source
Clinical heterogeneity in a family with flail arm syndrome and review of hnRNPA1‐related spectrum
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1910-1917, December 2022., 2022 Abstract Objective Flail arm syndrome (FAS) is one of the atypical subtypes of amyotrophic lateral sclerosis (ALS). Mutations in hnRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare genetic cause of ALS. Herein, marked clinical heterogeneity of FAS in a pedigree with a known hnRNPA1 variant was described to raise early ...
Xiaochen Han +5 more
wiley +1 more source
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model
EMBO Molecular Medicine, 2022 Single domain antibodies (VHHs) are potentially disruptive therapeutics, with important biological value for treatment of several diseases, including neurological disorders.
Marika Marino +22 more
doaj +1 more source