Results 111 to 120 of about 1,762,996 (326)

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

open access: yesAdvanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng   +19 more
wiley   +1 more source

Documenting the Brain Drain of «la Crème de la Crème»: Three Case-Studies on International Migration at the Upper Tail of the Education Distribution [PDF]

open access: yes
Most of the recent literature on the effects of the brain drain on source countries consists of theoretical papers and cross-country empirical studies. In this paper we complement the literature through three case studies on very different regional and ...
Hillel Rapoport, Frédéric Docquier
core  

Can Health Foreign Assistance Break the Medical Brain Drain? [PDF]

open access: yes
This paper analyses the impact of health foreign assistance on physicians' brain drain. We use the database from Bhargava and Docquier (2008) to explain physicians' brain drain and health foreign assistance from 1995 to 2003 using a bilateral gravity ...
Moullan, Yasser
core   +2 more sources

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

open access: yesAdvanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie   +12 more
wiley   +1 more source

Italy: Brain Drain or Brain Circulation?

open access: yesInternational Higher Education, 2018
Giving a Voice to Italian Scientists in Europe, a research project based on 83 in-depth interviews and a subsequent online survey, shows that transforming brain drain into brain circulation or into a potential scientific diaspora is not an easy task. Overturning Italy’s low level of investment in R&D and building reciprocal acknowledgment and trust
openaire   +3 more sources

Performance Estimation and Ex Vivo Validation of Untethered Magnetic Robots in Soft Tissue

open access: yesAdvanced Science, EarlyView.
This study presents an empirical model that quantitatively predicts the step‐out frequency of screw‐type untethered magnetic robots (UMRs) in soft viscoelastic environments, including ex vivo brain tissue. By integrating key parameters into a dimensionless framework, the model enables estimation of robot performance across a range of biological ...
Leendert‐Jan W. Ligtenberg   +19 more
wiley   +1 more source

Strategies to discourage brain drain

open access: yesBulletin of the World Health Organization, 2004
Building health research expertise in developing countries often requires personnel to receive training beyond national borders. For research funding agencies that sponsor this type of training, a major goal is to ensure that trainees return to their ...
Linda Kupfer   +4 more
doaj  

Third world brain drain

open access: yesBMJ, 2003
EDITOR–Respondents to Levy's article on the brain drain in the developing world1 have focused on the role of corrupt politicians and unstable governments in the developing world as the major …
openaire   +3 more sources

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