Results 111 to 120 of about 198,458 (304)

Whole-brain volumetric analysis of cerebral infarction.

, 2013
The whole-brain segmentation of cerebral infarction was accomplished by visual delination on T2-w RARE images. The infarct volume is given as percentage of the whole-brain volume.
Xavier Helluy (353754), Christoph Kleinschnitz (93826), Peter Jakob (202889), Martin Bendszus (299161), Andreas J. Bartsch (117824), Bernhard Nieswandt (93831), Mirko Pham (93829), Guido Stoll (21503), Peter Kraft (15118)   +8 more
core   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Brain infarction revealed by triphenyltetrazolium chloride (TTC) staining.

, 2013
(a) Rat brain (b) original TTC image of brain infarction after 90 minutes middle cerebral artery occlusion; and (c) image with labels. TTC reacts with dehydrogenases in viable cells and results in a “brick-red” color, and the white area indicates the ...
Shea Ping Yip (154416), Xiao-Xiang Zheng (356427), Le Li (356426), Kai-Yu Tong (356428), Zheng Ke (356425)   +4 more
core   +1 more source

Wearable‐Derived Diurnal Alignment Between Physical Activity and Device Temperature Predicts Future Disease and Mortality Risk

Advanced Science, EarlyView.
Wearable‐derived diurnal alignment between physical activity and device temperature, decomposed into 24 h coupling strength (M24), phase deviation (D24), and 12 h harmonic magnitude (M12), is examined in approximately 90,000 UK Biobank participants.
Han Chen, Jiahe Wei, Jonathan Cedernaes, Christian Benedict, Athanasios Tsanas, Zhi Cao, Xiao Tan   +6 more
wiley   +1 more source

Actions of alcohol and ischaemic brain infarction [PDF]

, 2000
Alcohol drinking may exercise both beneficial and untoward effects on the haemostatic and fibrinolytic systems. It may also predispose individuals to arterial thrombosis and trigger embolism in the brain.
Numminen, H. (Heikki)
core   +1 more source

Spontaneous cerebral hypothermia diminishes focal infarction in rat brain.

, 1992
Brain temperature during ischemia is known to strongly influence the extent of cellular injury. The objectives of the present study were to determine the effect of severe focal ischemia on brain temperature and to assess the influence of those changes on
E L Zager, D J Moyer, F A Welsh
core   +1 more source

Cavity Microelectrode Arrays for Electrical Recordings From Neurons

Advanced Electronic Materials, EarlyView.
Microelectrode arrays (MEAs) are used to study electrophysiological activity. However, their signals are small with high noise. By adding a 100‐nanometer‐high cavity above the electrode, which reduces impedance without affecting resolution, we improve signal quality.
Johannes Lewen, Bernhard Wolfrum, Andreas Offenhäusser   +2 more
wiley   +1 more source

The Impact of Early Postoperative Blood Pressure Variability and Hypertension Status on 90‐Day Functional Outcomes in Acute Ischemic Stroke due to Large Vessel Occlusion Patients Treated With Mechanical Thrombectomy

AGING MEDICINE, EarlyView.
Early postoperative blood pressure variability independently predicts poor 90‐day functional outcomes in AIS‐LVO patients after mechanical thrombectomy, with the adverse effect amplified in those with pre‐existing hypertension. Maintaining stable blood pressure in the early postoperative period may improve recovery in this high‐risk population ABSTRACT
Yunpeng Liu, Yiqi Liu, Zeping Jin, Jumei Huang, Yang Wang   +4 more
wiley   +1 more source

El Papel de las metaloproteinasas de matriz en la fase aguda del ictus isquémico

, 2004
El ictus cardioembólico o embolia cerebral de origen cardíaco es la oclusión de una arteria cerebral por un émbolo procedente del corazón. Con frecuencia origina infartos cerebrales de tamaño importante, presenta elevadas tasas de recanalización ...
Montaner Villalonga, Joan, Montaner, Joan   +1 more
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