Results 41 to 50 of about 882,811 (366)

Mapping how local perturbations influence systems-level brain dynamics [PDF]

Neuroimage 160:97-112 (2017), 2016
The human brain exhibits a relatively stable spatiotemporal organization that supports brain function and can be manipulated via local brain stimulation. Such perturbations to local cortical dynamics are globally integrated by distinct neural systems.
arxiv   +1 more source

Standardization of electroencephalography for multi-site, multi-platform and multi-investigator studies: Insights from the canadian biomarker integration network in depression [PDF]

, 2017
Subsequent to global initiatives in mapping the human brain and investigations of neurobiological markers for brain disorders, the number of multi-site studies involving the collection and sharing of large volumes of brain data, including ...
Alonso, Esther, Arnott, Stephen R., Atluri, Sravya, Blumberger, Daniel, Brenner, Colleen A., Daskalakis, Zafiris J., Dhami, Prabhjot, Dharsee, Moyez, Evans, Kenneth R., Farzan, Faranak, Frehlich, Matthew, Frey, Benicio N., Kennedy, Sidney H., Kleffner, Killian, Lam, Raymond W., Liotti, Mario, Mcandrews, Mary Pat, Milev, Roumen, Price, Rae, Ravindran, Arun, Rotzinger, Susan, Vila-Rodriguez, Fidel, Wong, Willy   +22 more
core   +1 more source

Molecular insights into the modulation of the 5HT2A receptor by serotonin, psilocin, and the G protein subunit Gqα

FEBS Letters, Volume 599, Issue 6, Page 876-891, March 2025.
We explore 5HT2A receptor activation, a key target for psychedelic drugs, using molecular dynamics simulations. Without Gqα, the active receptor collapses to an inactive conformation, underscoring the G‐protein's role. Discovery of an intermediate “partially‐open” state and the higher affinity of ligands to the orthosteric binding site provides ...
Niklas Viohl, Ali Asghar Hakami Zanjani, Himanshu Khandelia   +2 more
wiley   +1 more source

Phantom Sensations: What's a Brain to Do? A Critical Review of the Re-mapping Hypothesis [PDF]

, 2018
I will review the most widely held account of phantom sensations; the “re-mapping hypothesis.” According to the re-mapping hypothesis, amputation is followed by significant neural reorganization that, over time, restores the alignment between the brain’s
DeFranco, Daniel
core  

Rhythmic Representations: Learning Periodic Patterns for Scalable Place Recognition at a Sub-Linear Storage Cost

, 2017
Robotic and animal mapping systems share many challenges and characteristics: they must function in a wide variety of environmental conditions, enable the robot or animal to navigate effectively to find food or shelter, and be computationally tractable ...
Jacobson, Adam, Milford, Michael, Yu, Litao   +2 more
core   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, Volume 599, Issue 8, Page 1094-1112, April 2025.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Deep Cross-Modality and Resolution Graph Integration for Universal Brain Connectivity Mapping and Augmentation [PDF]

arXiv, 2022
The connectional brain template (CBT) captures the shared traits across all individuals of a given population of brain connectomes, thereby acting as a fingerprint. Estimating a CBT from a population where brain graphs are derived from diverse neuroimaging modalities (e.g., functional and structural) and at different resolutions (i.e., number of nodes)
arxiv  

Appendix A: “The Basic Postulates of Accounting” [PDF]

, 1965
Functional Magnetic Resonance Imaging (fMRI) is a relatively new imaging technique, first reported in 1992, which enables mapping of brain functions with high spatial resolution.
Ragnehed, Mattias
core   +1 more source

Electrical Stimulation Modulates High γ Activity and Human Memory Performance. [PDF]

, 2018
Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition.
Berry, Brent M., Davis, Kathryn A., Ezzyat, Youssef, Gorniak, MD, Richard, Gross, Robert E., Jobst, Barbara C., Kahana, Michael J., Khadjevand, Fatemeh, Kremen, Vaclav, Kucewicz, Michal T., Lega, Bradley, Miller, Laura R., Rizzuto, Daniel S., Sperling, Michael R., Stead, S Matt, Stein, Joel M., Wanda, Paul, Worrell, Gregory A,   +17 more
core   +2 more sources

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source