Results 61 to 70 of about 882,811 (366)

Mapping the Alzheimer’s Brain with Connectomics [PDF]

Frontiers in Psychiatry, 2012
Alzheimer's disease (AD) is the most common form of dementia. As an incurable, progressive, and neurodegenerative disease, it causes cognitive and memory deficits. However, the biological mechanisms underlying the disease are not thoroughly understood.
Teng Xie, Yong He
openaire   +4 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Deep Representation Learning For Multimodal Brain Networks [PDF]

arXiv, 2020
Applying network science approaches to investigate the functions and anatomy of the human brain is prevalent in modern medical imaging analysis. Due to the complex network topology, for an individual brain, mining a discriminative network representation from the multimodal brain networks is non-trivial. The recent success of deep learning techniques on
arxiv  

A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale [PDF]

, 2009
In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is however critical both for basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap,
A MacKenzie-Graham, A Reiner, A Vercelli, A Visel, Allan Jones, AM Hattox, Arthur W. Toga, AW Toga, AY Hardan, B Egaas, B Horwitz, BL Davidson, Brett D. Mensh, Bruce W. Stillman, C Gustafson, C Kobbert, Caizhi Wu, CL Veenman, Claus C. Hilgetag, Clifford B. Saper, CR Gerfen, D Atasoy, DA Benson, Daniel G. Herrera, David C. Van Essen, David Kleinfeld, DC Van Essen, DC Van Essen, DL Sparks, E Miyashita, ED Jarvis, Edward G. Jones, EM Callaway, ES Lein, ET Bullmore, F Castelli, F Crick, G Aston-Jones, H Markram, Hans C. Breiter, Harvey J. Karten, HC Breiter, Helen Barbas, Hemant Bokil, Henry A. Lester, Hollis T. Cline, IR Wickersham, J DeFalco, J Dejerine, J Panksepp, J Panksepp, Jaak Panksepp, James D. Watson, Jason W. Bohland, JD Schmahmann, Jeremy D. Schmahmann, JF Démonet, JG Bjaalie, JG Bjaalie, JG Bjaalie, JG White, JL Lanciego, JM Lin, John C. Doyle, John M. Lin, Joseph L. Price, Joseph Safdieh, K Oishi, K Wernicke, Karel Svoboda, KE Stephan, KE Stephan, L Ng, L Stein, Larry W. Swanson, LM Coolen, M Bota, M Bota, M Bota, M Murias, MA Just, MD Johnson, MI Ekstrand, Michael Hawrylycz, Mihail Bota, MJ Swift, N Geschwind, Nicholas D. Schiff, O Sporns, Olaf Sporns, Partha P. Mitra, Peter J. Freed, PH Luppi, PJ Broser, R Kotter, R Kotter, Ralph J. Greenspan, RH Güting, RM Kelly, Rolf Kötter, RW Baughman, S Folstein, S Lillehaug, S Mikula, Shawn Mikula, Suzanne N. Haber, U Burgel, U Frith, V Grinevich, Z. Josh Huang   +109 more
core   +8 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Retinotopy Inspired Brain Encoding Model and the All-for-One Training Recipe [PDF]

arXiv, 2023
Brain encoding models aim to predict brain voxel-wise responses to stimuli images, replicating brain signals captured by neuroimaging techniques. There is a large volume of publicly available data, but training a comprehensive brain encoding model is challenging.
arxiv  

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

A Twin Study of Genetic Contributions to Hippocampal Morphology in Schizophrenia

Neurobiology of Disease, 2002
Our goal was to establish whether altered hippocampal morphology represents a trait marker for genetic vulnerability in schizophrenia. We outlined the hippocampi on high-resolution MR images obtained from matched samples of control and discordant ...
Katherine L. Narr, Theo G.M. van Erp, Tyrone D. Cannon, Roger P. Woods, Paul M. Thompson, Seonah Jang, Rebecca Blanton, Veli-Pekka Poutanen, Matti Huttunen, Jouko Lönnqvist, Carl-Gustav Standerksjöld-Nordenstam, Jaakko Kaprio, John C. Mazziotta, Arthur W. Toga   +13 more
doaj  

Mapping effective connectivity by virtually perturbing a surrogate brain [PDF]

arXiv, 2022
Effective connectivity (EC), indicative of the causal interactions between brain regions, is fundamental to understanding information processing in the brain. Traditional approaches, which infer EC from neural responses to stimulations, are not suited for mapping whole-brain EC in humans due to being invasive and having limited spatial coverage of ...
arxiv  

Mapping cognitive ontologies to and from the brain [PDF]

, 2013
Imaging neuroscience links brain activation maps to behavior and cognition via correlational studies. Due to the nature of the individual experiments, based on eliciting neural response from a small number of stimuli, this link is incomplete, and ...
Schwartz, Yannick, Thirion, Bertrand, Varoquaux, Gaël   +2 more
core   +3 more sources