Results 61 to 70 of about 764,568 (342)
Geometry Processing of Conventionally Produced Mouse Brain Slice Images
, 2017 Brain mapping research in most neuroanatomical laboratories relies on conventional processing techniques, which often introduce histological artifacts such as tissue tears and tissue loss.
Agarwal, Nitin +2 more
core +1 more source
Three-dimensional scanless holographic optogenetics with temporal focusing (3D-SHOT). [PDF]
, 2017 Optical methods capable of manipulating neural activity with cellular resolution and millisecond precision in three dimensions will accelerate the pace of neuroscience research. Existing approaches for targeting individual neurons, however, fall short of
Adesnik, Hillel +5 more
core +2 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
A randomized open-label clinical trial on the effect of Amantadine on post Covid 19 fatigue
Scientific ReportsMany COVID-19 survivors experience lingering post-COVID-19 symptoms, notably chronic fatigue persisting for months after the acute phase. Despite its prevalence, limited research has explored effective treatments for post-COVID-19 fatigue.
Ali Amini Harandi +9 more
doaj +1 more source
Dwelling Quietly in the Rich Club: Brain Network Determinants of Slow Cortical Fluctuations
, 2015 For more than a century, cerebral cartography has been driven by investigations of structural and morphological properties of the brain across spatial scales and the temporal/functional phenomena that emerge from these underlying features.
Breakspear, Michael +4 more
core +1 more source
A working model for cytoplasmic assembly of H/ACA snoRNPs
FEBS Letters, EarlyView.Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source
EEG Microstates in Altered States of Consciousness
Frontiers in Psychology, 2022 Conscious experiences unify distinct phenomenological experiences that seem to be continuously evolving. Yet, empirical evidence shows that conscious mental activity is discontinuous and can be parsed into a series of states of thoughts that manifest as ...
Lucie Bréchet +3 more
doaj +1 more source
Mapping the Alzheimer’s Brain with Connectomics [PDF]
Frontiers in Psychiatry, 2012 Alzheimer's disease (AD) is the most common form of dementia. As an incurable, progressive, and neurodegenerative disease, it causes cognitive and memory deficits. However, the biological mechanisms underlying the disease are not thoroughly understood.
Teng Xie, Yong He
openaire +4 more sources
Novel and unscrutinized immune entities of the zebrafish gut
FEBS Letters, EarlyView.Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
wiley +1 more source