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Natriuretic Peptide Actions in the Brain [PDF]

, 1997
The discovery of atrial natriuretic peptide (ANP) in the heart some 15 yr ago (1) prompted an explosion of research directed toward understanding both the integrated physiological roles and the potential sites of action of this vasoactive peptide. These studies pointed to the central nervous system (CNS), and in particular to regions of the brain with ...
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The Diagnostic and Prognostic Value of Brain Natriuretic Peptide and Aminoterminal (nt)-pro Brain Natriuretic Peptide

Current Pharmaceutical Design, 2005
The discovery of B-type natriuretic peptide (BNP) and n-terminal pro BNP (nt-proBNP) as markers for the diagnosis, severity and prognosis of patients with congestive heart failure has been called a true breakthrough for patients and physicians faced with this disorder. Moreover, the literature on their prognostic value in other clinical conditions like
Bernd Eber, Thomas Weber, Johann Auer
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Monoclonal antibody against brain natriuretic peptide and characterization of brain natriuretic peptide-transgenic mice

Journal of Hypertension, 2001
Brain natriuretic peptide (BNP) is a ventricular hormone with natriuretic, diuretic and vasodilatory actions. Acute infusion of BNP reduces cardiac pre- and after-load in healthy and diseased subjects, but its long-term therapeutic usefulness remains unclear.We prepared a monoclonal antibody specific to mouse BNP, and characterized transgenic mice ...
Osamu Nakagawa, Yoshihiro Ogawa, Akira Sugawara, Masashi Mukoyama, Issei Tanaka, Shin Ichi Suga, Naohisa Tamura, Rieko Ishibashi, Kazuwa Nakao, Masahisa Goto, Masayo Nakagawa   +10 more
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Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic left ventricular dysfunction.

Circulation, 1997
BACKGROUND Patients with congestive heart failure (CHF) have high plasma levels of atrial natriuretic peptide (ANP), mainly from the atrium, and brain natriuretic peptide (BNP), mainly from the ventricle.
T. Tsutamoto, A. Wada, K. Maeda, T. Hisanaga, Y. Maeda, D. Fukai, M. Ohnishi, Y. Sugimoto, M. Kinoshita   +8 more
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Pulsatile secretion of atrial natriuretic peptide and brain natriuretic peptide in healthy humans

Clinical Science, 1999
Both atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are involved in sodium and water homoeostasis in healthy humans. The plasma concentrations of the natriuretic peptides can be used to differentiate between dyspnoea of cardiac and pulmonary origin, and the degree of elevation of the peptide levels in the plasma in heart failure ...
Pedersen, Erling Bjerregaard, Pedersen, Henrik B., Jensen, K. T.   +2 more
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Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide.

Endocrinology, 1992
To elucidate the ligand-receptor relationship of the natriuretic peptide system, which comprises at least three endogenous ligands, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and three receptors, the ANP-A receptor or guanylate cyclase-A (GC-A), the ANP-B receptor or guanylate cyclase-B (GC ...
Hiroshi Arai, Kazuwa Nakao, Masashi Mukoyama, Shin Ichi Suga, Gotaro Shirakami, Yoshikazu Kambayashi, Yoshihiro Ogawa, Yoshihiko Saito, Kiminori Hosoda, Ken Inouye   +9 more
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The action of two natriuretic peptides (atrial natriuretic peptide and brain natriuretic peptide) in the human placental vasculature

American Journal of Obstetrics and Gynecology, 1995
Our purpose was to compare the actions of atrial natriuretic peptide and brain natriuretic peptide in the human placental vasculature.Isolated placental cotyledons were dually perfused with fetal perfusion pressure used as an index of vascular response.
W. Kossenjans, Gershon Holcberg, Anthony S. Brewer, Leslie Myatt, Menachem Miodovnik   +4 more
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Atrial Natriuretic Peptide and Brain Natriuretic Peptide in Cor Pulmonale

Chest, 1996
We have studied the hemodynamic and hormonal effects of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in eight patients with cor pulmonale. Subjects were studied twice and were given a 20-min placebo infusion followed by either ANP or BNP (3 pmol/kg/min then 10 pmol/kg/ min for 20 min each).
Brian J. Lipworth, Robert I. Cargill
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Plasma brain natriuretic peptide and C-type natriuretic peptide in essential hypertension

Journal of Hypertension, 1994
To study the relationship between hypertension and the plasma levels of brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP), and to determine whether the plasma levels of BNP and CNP are correlated.A cross-sectional study of the plasma levels of BNP and CNP in hypertensive patients and normotensive controls matched for age and sex was ...
Brown, MJ, Cheung, BM
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Brain Natriuretic Peptide and Atrial Natriuretic Peptide Levels in Normal Pregnancy and Preeclampsia

Gynecologic and Obstetric Investigation, 1994
Brain natriuretic peptide (BNP) was increased in many hypertensive subjects. In this study, we have evaluated maternal, umbilical plasma and amniotic fluid BNP and atrial natriuretic peptide (ANP) in 19 normotensive pregnant women and in 35 preeclamptic patients.
H Kimura, C. Kimura, H. Nagae, T. Saito, Nobuaki Furuhashi, Akira Yajima   +5 more
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