Results 51 to 60 of about 182,203 (309)

Order-of-mutation effects on cancer progression: models for myeloproliferative neoplasm [PDF]

open access: yesarXiv, 2023
We develop a modeling framework for cancer progression that distinguishes the order of two possible mutations. Recent observations and information on myeloproliferative neoplasms are analyzed within our framework. In some patients with myeloproliferative neoplasms, two genetic mutations can be found, JAK2 V617F and TET2.
arxiv  

BlazeNeo: Blazing fast polyp segmentation and neoplasm detection [PDF]

open access: yesarXiv, 2022
In recent years, computer-aided automatic polyp segmentation and neoplasm detection have been an emerging topic in medical image analysis, providing valuable support to colonoscopy procedures. Attentions have been paid to improving the accuracy of polyp detection and segmentation.
arxiv  

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

open access: yesFEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher   +6 more
wiley   +1 more source

Neuroplasticity of Glioma Patients: Brain Structure and Topological Network

open access: yesFrontiers in Neurology, 2022
Glioma is the most common primary malignant brain tumor in adults. It accounts for about 75% of such tumors and occurs more commonly in men. The incidence rate has been increasing in the past 30 years. Moreover, the 5-year overall survival rate of glioma
Kun Lv   +18 more
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi   +3 more
wiley   +1 more source

Improving Maximal Safe Brain Tumor Resection with Photoacoustic Remote Sensing Microscopy [PDF]

open access: yesarXiv, 2020
Malignant brain tumors are among the deadliest neoplasms with the lowest survival rates of any cancer type. In considering surgical tumor resection, suboptimal extent of resection is linked to poor clinical outcomes and lower overall survival rates.
arxiv  

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

open access: yesMolecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen   +13 more
wiley   +1 more source

Interhemispheric lipoma with callosal dysgenesis [PDF]

open access: yesArchive of Oncology, 2006
Intracranial lipomas are uncommon benign lesions of the central nervous system. Intracranial lipomas are usually asymptomatic and an occasional finding.
Prvulović Nataša   +3 more
doaj   +1 more source

NeoUNet: Towards accurate colon polyp segmentation and neoplasm detection [PDF]

open access: yesarXiv, 2021
Automatic polyp segmentation has proven to be immensely helpful for endoscopy procedures, reducing the missing rate of adenoma detection for endoscopists while increasing efficiency. However, classifying a polyp as being neoplasm or not and segmenting it at the pixel level is still a challenging task for doctors to perform in a limited time.
arxiv  

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

open access: yesMolecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi   +6 more
wiley   +1 more source

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