Results 111 to 120 of about 643,416 (317)

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Phase-dependent closed-loop deep brain stimulation of the fornix provides bidirectional manipulation of hippocampal theta oscillations

Brain Stimulation
Introduction: Alzheimer's disease (AD) has very limited treatment options and therapies to prevent or reverse neurodegeneration remain elusive. Deep brain stimulation (DBS), whereby high-frequency pulses of electricity are delivered continuously to a ...
Isaac Grennan, Brook Perry, Anna Verghese, Melissa Jones, Oliver Härmson, Colin G. McNamara, Andrew Sharott   +6 more
doaj   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

SNAP-23 mediated vesicular trafficking in oligodendrocytes is necessary to maintain adult myelin integrity in mice

Nature Communications
Adult myelin is dynamic and requires continuous support from oligodendrocytes. Inability to sustain myelin health results in demyelination, evident in multiple sclerosis and neurodegenerative diseases.
Chun Hin Chow, Mengjia Huang, Aryan Regmi, Jayant Rai, Hidekiyo Harada, Sarah Eide, Hong-Shuo Sun, Zhong-Ping Feng, Philippe P. Monnier, Kenichi Okamoto, Liang Zhang, Olga L. Rojas, Shuzo Sugita   +12 more
doaj   +1 more source

Cortical beta oscillations help synchronise muscles during static posture holding in healthy motor control

NeuroImage
How cortical oscillations are involved in the coordination of functionally coupled muscles and how this is modulated by different movement contexts (static vs dynamic) remains unclear.
Thomas G. Simpson, William Godfrey, Flavie Torrecillos, Shenghong He, Damian M. Herz, Ashwini Oswal, Muthuraman Muthuraman, Alek Pogosyan, Huiling Tan   +8 more
doaj   +1 more source

Stable brain networks [PDF]

Nature Human Behaviour, 2018
openaire   +2 more sources

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Effect of Transcranial random noise stimulation on medial prefrontal cortex governing inhibitory control

Brain Stimulation, 2023
Alekhya Mandali, Flavie Torrecillos, Carolina Reis, Christoph Wiest, Alek Pogosyan, Huiling Tan, Hayriye Cagnan   +6 more
doaj   +1 more source

The Impact of Spinal Cord Neuromodulation on Restoration of Walking Ability After Spinal Cord Injury [PDF]

Neurospine, 2022
Michael G. Fehlings, Alexander A. Velumian   +1 more
doaj   +1 more source

Author response for "Brain‐wide mapping of inputs to the mouse lateral posterior (LP/Pulvinar) thalamus–anterior cingulate cortex network"

, 2022
Yi Ning Leow, Blake Zhou, Heather Sullivan, Alexandria R. Barlowe, Ian R. Wickersham, Mriganka Sur   +5 more
openalex   +1 more source