Results 41 to 50 of about 643,416 (317)

Problematic internet use in children and adolescents: associations with psychiatric disorders and impairment

BMC Psychiatry, 2020
Background Problematic internet use (PIU) is an increasingly worrisome issue, as youth population studies are establishing links with internalizing and externalizing problems.
Anita Restrepo, Tohar Scheininger, Jon Clucas, Lindsay Alexander, Giovanni A. Salum, Kathy Georgiades, Diana Paksarian, Kathleen R. Merikangas, Michael P. Milham   +8 more
doaj   +1 more source

Animal‐Assisted Activities With Therapy Dogs in Pediatric Oncology: A Multicenter Survey of the Current Status, Implementation, and Challenges in Germany, Austria, and Switzerland

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Animal‐assisted activities (AAAs) with therapy dogs have shown positive effects on patient well‐being and quality of life in various areas of medicine, including pediatric oncology. However, research on this topic is limited. The aim of this study is to present the current status of AAA in pediatric oncology in Germany, Austria, and
Jan‐Marius Wedig, Birgit Burkhardt, Christof M. Kramm, Kira Ostermann, Sarah C. Goretzki, Uta Dirksen, Nico Kurpiers, Michael M. Schündeln   +7 more
wiley   +1 more source

Neuroethical issues in adopting brain imaging for personalized chronic pain management: Attitudes of people with lived experience of chronic pain

Canadian Journal of Pain
Background Pain is an individual and subjective experience that places a burden on individuals to convince others they have pain. Brain imaging technologies can potentially inform pain management but raise neuroethical questions.Aims We examined the ...
Karen Deborah Davis, Monica de Oliveira, Ariana Besik, Daniel Z. Buchman   +3 more
doaj   +1 more source

The Development of Brain Network Hubs

Developmental Cognitive Neuroscience, 2018
Some brain regions have a central role in supporting integrated brain function, marking them as network hubs. Given the functional importance of hubs, it is natural to ask how they emerge during development and to consider how they shape the function of the maturing brain.
Stuart Oldham, Alex Fornito
openaire   +5 more sources

Heteroclinic networks for brain dynamics

Frontiers in Network Physiology, 2023
Heteroclinic networks are a mathematical concept in dynamic systems theory that is suited to describe metastable states and switching events in brain dynamics. The framework is sensitive to external input and, at the same time, reproducible and robust against perturbations.
Hildegard Meyer-Ortmanns, Hildegard Meyer-Ortmanns   +1 more
openaire   +3 more sources

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

MIR1255A regulates pathways critical for brain development, risk genes for depression and neurodevelopmental disorders

Translational Psychiatry
Multiple lines of evidence implicate microRNAs (miRNAs) in major depressive disorder (MDD), including the location of miRNAs genes (MIRs) within genomic regions identified by genome wide association studies (GWAS).
Yu Feng, Karen G. Wigg, Cathy L. Barr
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

AAV9-mediated KCC2 upregulation enhances functional recovery following cervical spinal cord injury

Communications Biology
Following traumatic cervical spinal cord injury (SCI), injury-induced functional changes within the perilesional forelimb circuits are an important cause of neurological dysfunction.
Mohammad-Masoud Zavvarian, Akshat D. Modi, Mohamad Khazaei, Zixiang Luo, Alexander R. Velumian, Omar Imad Hassan, James Hong, Christopher S. Ahuja, Zeenal H. Patel, Miao He, Zhigang He, Michael G. Fehlings   +11 more
doaj   +1 more source