Results 71 to 80 of about 643,416 (317)
Journal of Neuropathology & Experimental Neurology, 2014 Networks of the Brain Olaf Sporns The MIT Press, Cambridge, MA, 2011 412 pages; $45.00 Networks of the Brain by Olaf Sporns presents a theoretically and empirically based introduction to neural networks. The text is thoughtfully arranged beginning with terminology and concepts that establish the background for the content of the book.
openaire +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Diurnal modulation of optogenetically evoked neural signals
Neuroscience ResearchNeural signal processing in the cerebral cortex is often regarded as robust and stereotyped; however, the brain’s internal environment undergoes dynamic fluctuations across the day.
Yuki Donen, Yoko Ikoma, Ko Matsui
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Neuroscience ResearchAnger transition is often abrupt. In this study, we investigated the mechanisms responsible for switching and modulating aggression levels. The cerebellum is considered a center for motor coordination and learning; however, its connection to social ...
Yuki Asano +3 more
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Psychophysical data to study the brain network mechanisms involved in reorienting attention to salient events during goal-directed visual discrimination and search tasks [PDF]
, 2021 Priyanka Ghosh +2 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Closed-loop phase-dependent optogenetic modulation of motor cortical theta oscillations
Brain Stimulation, 2023 Jessica Myatt +7 more
doaj +1 more source