Results 61 to 70 of about 391,425 (267)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Neuroimaging of Brain Networks and Function [PDF]

BioMed Research International, 2015
The human brain consists of multiple interconnected large scale networks. Recent advances in structural and functional neuroimaging techniques have introduced new concepts and approaches to noninvasively assess brain networks, which has attracted enormous research interest.
Rao, Hengyi, Wang, Danny Jiongjiong, Yang, Yihong, He, Yong   +3 more
openaire   +4 more sources

Optimizing and assessing multichannel TMS focality

Brain Stimulation
Background: Multichannel transcranial magnetic stimulation (mTMS) enables electronic steering of induced electric fields across multiple cortical targets without physical coil repositioning, addressing key limitations of conventional single-channel TMS ...
Ole Numssen, Carla W. Martin, Torge Worbs, Axel Thielscher, Konstantin Weise, Thomas R. Knösche   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The development of brain network architecture [PDF]

Human Brain Mapping, 2015
AbstractBrain connectivity shows protracted development throughout childhood and adolescence, and, as such, the topology of brain networks changes during this period. The complexity of these changes with development is reflected by regional differences in maturation. This study explored age‐related changes in network topology and regional developmental
Wierenga, Lara M., van den Heuvel, Martijn P., van Dijk, Sarai, Rijks, Yvonne, de Reus, Marcel A., Durston, Sarah   +5 more
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Dynamic Networks in the Emotional Brain [PDF]

The Neuroscientist, 2016
Research on the emotional brain has often focused on a few structures thought to be central to this type of processing—hypothalamus, amygdala, insula, and so on. Conceptual thinking about emotion has viewed this mental faculty as linked to broader brain circuits, too, including early ideas by Papez and others.
Luiz, Pessoa, Brenton, McMenamin
openaire   +2 more sources

Altered Basal Ganglia Network Topology Associated With Auditory–Motor Synchronization

Brain and Behavior
Introduction Auditory–motor synchronization (AMS) embedded in Rhythmic Auditory Stimulation (RAS) is a validated method to improve gait, upper limb function, and motor speech in people with neurologic disorders like Parkinson's disease (PD).
Stéphanie K. Lavigne, Jonathan H. Burdette, Mohsen Bahrami, Paul J. Laurienti, Robert G. Lyday, Michael H. Thaut   +5 more
doaj   +1 more source

Concierge: Personal database software for managing digital research resources

Frontiers in Neuroinformatics, 2007
This article introduces a desktop application, named Concierge, for managing personal digital research resources. Using simple operations, it enables storage of various types of files and indexes them based on content descriptions.
Hiroyuki Sakai, Toshihiro Aoyama, Kazutsuna Yamaji, Shiro Usui   +3 more
doaj   +1 more source